DNA Methylation and Mismatch Repair: Molecular Specificities

  • Miroslav Radman
Part of the NATO ASI Series book series (volume 137)


A DNA base pair mismatch can be defined as any non-complementary base pair in the DNA duplex. Such DNA duplex carrying mismatched, or unpaired, bases is called DNA heteroduplex. A DNA heteroduplex is characterized by non-identical genetic information of the two complementary strands, such that upon DNA replication a single heteroduplex molecule segregates genetically, i.e. yields mixed progeny consisting of DNA duplexes with the sequence of individual heteroduplex strands. The mismatch repair process transforms a heteroduplex molecule into a homoduplex which yields pure progeny of a single genotype.


Mismatch Repair Sister Chromatid Exchange Replication Error Mismatch Repair System Unpaired Basis 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Miroslav Radman
    • 1
  1. 1.Institut Jacques MonodC. N. R. S.Paris Cedex 05France

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