DNA Methylation and Mismatch Repair: Molecular Specificities

  • Miroslav Radman
Part of the NATO ASI Series book series (volume 137)


A DNA base pair mismatch can be defined as any non-complementary base pair in the DNA duplex. Such DNA duplex carrying mismatched, or unpaired, bases is called DNA heteroduplex. A DNA heteroduplex is characterized by non-identical genetic information of the two complementary strands, such that upon DNA replication a single heteroduplex molecule segregates genetically, i.e. yields mixed progeny consisting of DNA duplexes with the sequence of individual heteroduplex strands. The mismatch repair process transforms a heteroduplex molecule into a homoduplex which yields pure progeny of a single genotype.


Mismatch Repair Sister Chromatid Exchange Replication Error Mismatch Repair System Unpaired Basis 


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  1. Abastado, J.P., Cami, B., Dinh, T.H., Igolen, J., and Kourilsky, P., 1984, Proc. Natl. Acad, Sci, USA, 81:5792–5796.CrossRefGoogle Scholar
  2. Barbeyron, T., Kean, K., and Forterre, P., 1984, J. Bact., 160:586–590.PubMedGoogle Scholar
  3. Brenner, D.A., Smigocki, A.C., and Camerini-Otero, D.R., 1986, Proc. Natl. Acad. Sci. USA, 83:1762–1766.PubMedCrossRefGoogle Scholar
  4. Choy, H.E., and Fowler, R.G., 1985, Mut. Res., 142:93–97.CrossRefGoogle Scholar
  5. Claverys, J.P., Mejean, V., Gasc, A.M., and Sicard, A.M., 1983, Proc. Natl. Acad. Sci. USA, 80:5956–5960.PubMedCrossRefGoogle Scholar
  6. Coulondre, C., Miller, J.H., Farabaugh, P.J., and Gilbert, W., 1978, Nature 274:775–780.PubMedCrossRefGoogle Scholar
  7. Dohet, C., Wagner, R., and Radman, M., 1985, Proc. Natl. Acad. Sci. USA 82:503–505.PubMedCrossRefGoogle Scholar
  8. Dohet, C., Wagner, R., and Radman, M., 1986, Proc. Natl. Acad. Sci. USA, 83:3395–3397.PubMedCrossRefGoogle Scholar
  9. Dohet, C., Dzidic, S., Wagner, R., and Radman, M., 1987, Mol. Gen. Genet. 206:181–184.PubMedCrossRefGoogle Scholar
  10. Fazakerley, G.V., Quignard, E., Woisard, A., Guschlbauer, W., van der Marel, G.A., van Boom, J.H., Jones, M., and Radman, M., 1986, EMBO J., 5:3697–3703.PubMedGoogle Scholar
  11. Folger, K.R., Thomas, K., and Capecchi, M.R., 1985, Mol. Cell. Biol. 5:70–74.PubMedGoogle Scholar
  12. Geier, G.E., and Modrich, P.J., 1979, J. Biol. Chem., 254:1408–1413.PubMedGoogle Scholar
  13. Glickman, B.W., van der Elsen, P., and Radman, M., 1978, Mol. Gen. Genet. 163:307–312.PubMedCrossRefGoogle Scholar
  14. Glickman, B.W., and Radman, M., 1980, Proc. Natl. Acad. Sci. USA, 77:1063–1067.PubMedCrossRefGoogle Scholar
  15. Glickman, B.W., Fix, D.E., Tatagai, F., Burns, P.A., and Schaaper, R.M., 1966, in: Mechanisms of DNA damage and repair. Simic, M., Grossman, L., and Upton, A., Eds. Plenum Press, N.Y. 425–438.Google Scholar
  16. Hare, J.T., and Taylor, H., 1985, Proc. Natl. Acad. Sci. USA, 82:7350–7354.PubMedCrossRefGoogle Scholar
  17. Hattman, S., 1981, The Enzymes, 14:517–548.CrossRefGoogle Scholar
  18. Hunter, W.N., Brownn, T., Anand, N.N., and Kennard, O., 1986, Nature, 320:552–555.PubMedCrossRefGoogle Scholar
  19. Jones, M., and Wagner, R., 1981, Mol. Gen. Genet., 184:562–563.PubMedCrossRefGoogle Scholar
  20. Jones, M., Wagner, R., and Radman, M., 1987a, Genetics, in press.Google Scholar
  21. Jones, M., Wagner, R., and Radman, M., 1987b, J. Mol. Biol., in press.Google Scholar
  22. Karran, P., and Marinus, M.G., 1982, Nature, 296:868–869.PubMedCrossRefGoogle Scholar
  23. Kourilsky, P., 1983, Biochimie, 65:85–93.PubMedCrossRefGoogle Scholar
  24. Kramer, W., Schughart, K., and Fritz, H.J., 1982, Nucl. Acids. Res. 10:6475–6485.PubMedCrossRefGoogle Scholar
  25. Kramer, B., Kramer, W., and Fritz, H.J., 1984, Cell, 38:879–881.PubMedCrossRefGoogle Scholar
  26. Kumura, K., and Sekiguchi, M., 1984, J. Biol. Chem., 259:1560–1565.PubMedGoogle Scholar
  27. Lacks, S.A., Dunn, J.J., and Greenberg, B., 1982, Cell, 31:327–336.PubMedCrossRefGoogle Scholar
  28. Längle-Rouault, F., Maenhaut-Michel, G., and Radman, M., 1986, EMBO J., 5:2009–2013.Google Scholar
  29. Längle-Rouault, F., Maenhaut-Michel, G., and Radman, M., 1987, EMBO J., submitted.Google Scholar
  30. Leong, P.M., Hsia, H.C., and Miller, J.H., 1986, J. Bact. 168:412–416.PubMedGoogle Scholar
  31. Lichten, M.J., and Fox, M.S., 1984, Proc. Natl. Acad. Sci. OSA, 81: 7180–7184.CrossRefGoogle Scholar
  32. Lieb, M., 1983, Mol. Gen. Genet., 191:118–125.PubMedCrossRefGoogle Scholar
  33. Lieb, M., 1985, Mol. Gen. Genet., 199:465–470.PubMedCrossRefGoogle Scholar
  34. Lindahl, T., 1982, Annu. Rev. Biochem., 51:61–87.PubMedCrossRefGoogle Scholar
  35. Lu, A.L., Clark, S., and Modrich, P., 1983, Proc. Natl. Acad. Sci. USA, 80:4639–4643.PubMedCrossRefGoogle Scholar
  36. Lu, A.L., Welsh, K., Su, S.S. and Modrich, P., 1984, Cold Spring Harbor Symp. Quant. Biol., 49:589–596.PubMedCrossRefGoogle Scholar
  37. Lyons, S.M., and Schendel, P.F., 1984, J. Bact., 159:421–423.PubMedGoogle Scholar
  38. Marinus, M.G., and Morris, N.R., 1975, Mutat. Res., 28:15–26.PubMedCrossRefGoogle Scholar
  39. Matson, S.W., 1986, J. Biol. Chem., 261:10169–10175.PubMedGoogle Scholar
  40. Matson, S.W., and George, J.W., 1987, J. Biol. Chem., accepted.Google Scholar
  41. Natarajan, A.T., Mullenders, L.H.F., Meijers, M., and Mukherjee, U., 1985, Mut. Res. 144:33–39.CrossRefGoogle Scholar
  42. Pang, P.P., Lundberg, A.S., and Walker, G.C., 1985, J. Bact., 163:1007–1015.PubMedGoogle Scholar
  43. Pardi, A., Morden, K.M., Patel, D.J., and Tinoco, I. Jr., 1982, Biochemistry, 21:6567–6574.PubMedCrossRefGoogle Scholar
  44. Petruska, J., and Goodman, M.F., 1986, J. Biol. Chem., 260:7533–7539.Google Scholar
  45. Proffitt, J.H., Davie, J.R., Swinton, D., and Hattman, S., 1984, Mol. Cell. Biol., 4:985–988.PubMedGoogle Scholar
  46. Pukkila, P.J., Peterson, J., Herman, G., Modrich, P., and Meselson, M., 1983, Genetics, 104:571–582.PubMedGoogle Scholar
  47. Radman, M., Wagner, R.E., Glickman, B.W., and Meselson, M., 1980, in: Progress in Environmental Mutagenesis, Alacevic, M. ed., Elsevier, Amsterdam, 121–130.Google Scholar
  48. Radman, M., 1983, UCLA Symp. Mol. Cell. Biol., 11:287–298.Google Scholar
  49. Radman, M., Dohet, C., Jones, M., Doutriaux, M.P., Längle-Rouault, F., Maenhaut-Michel, G., and Wagner, R., 1985, Biochimie, 66:745–752.CrossRefGoogle Scholar
  50. Radman, M., and Wagner, R., 1986, Annu. Rev. Genet., 20:523–538.PubMedCrossRefGoogle Scholar
  51. Rydberg, B., 1978, Mutat. Res., 52:11–24.PubMedCrossRefGoogle Scholar
  52. Shanabruch, W.G., Rein, R.P., Behlau, I., and Walker, G.C., 1983, J. Bact. 153:33.PubMedGoogle Scholar
  53. Skopek, T.R., and Hutchinson, F., 1984, Mol. Gen. Genet., 195:418–423.PubMedCrossRefGoogle Scholar
  54. Su, S.S., and Modrich, P., 1986, Proc. Natl. Acad. Sci. USA 83:5057–5061.PubMedCrossRefGoogle Scholar
  55. Wagner, R., Dohet, C., Jones, M., Doutriaux, M.P., Hutchinson, F. and Radman, M., 1984, Cold Spring Harbor Symp. Quant. Biol., 49:611–615.PubMedCrossRefGoogle Scholar
  56. Welsh, K.M., Lu, A.L., and Modrich, P., 1986, Fed. Proc, 45: abst.1758.Google Scholar
  57. Werntges, H., Steger, G., Riesner, D., and Fritz, H.F., 1986, Nucleic Acids Res., 14:3773–3790.PubMedCrossRefGoogle Scholar
  58. White, J.H., Lusnak, K., and Foger, S., 1985, Nature, 315:350–352.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Miroslav Radman
    • 1
  1. 1.Institut Jacques MonodC. N. R. S.Paris Cedex 05France

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