Evidence for Central Nervous System Insulin Synthesis

  • Derrel W. Clarke
  • Jennifer J. Poulakos
  • Laura M. Mudd
  • Mohan K. Raizada
  • David L. Cooper


Since Havrankonva and co-workers described the widespread distribution of both insulinl and insulin receptors2 in the rat central nervous system (CNS), two basic questions have remained unanswered. The first is the source of this insulin within the CNS, whether locally produced or of pancreatic origin. Second is the function of insulin within the CNS. Does insulin have similar effects. centrally to those outside the CNS or does insulin have unique functions in the CNS?


High Performance Liquid Chromatography Porcine Insulin Immunoreactive Insulin Insulin Synthesis Brain Insulin 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Derrel W. Clarke
    • 1
  • Jennifer J. Poulakos
    • 1
  • Laura M. Mudd
    • 2
  • Mohan K. Raizada
    • 2
  • David L. Cooper
    • 3
  1. 1.Departments of PediatricsUniversity of Florida College of MedicineGainesvilleUSA
  2. 2.Departments of PhysiologyUniversity of Florida College of MedicineGainesvilleUSA
  3. 3.Departments of PathologyUniversity of Florida College of MedicineGainesvilleUSA

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