The Processing and Transport of Peptide Hormones Across Endothelial Cell Barriers
Transcytosis is the transcellular transport of substances from one side of the cell to the other side within vesicles. Transported substances are taken up by endocytosis at one plasma membrane surface and are released via exocytosis at a different surface, which allows these substances to bypass intercellular junctions. The term was originally proposed for vesicular transport across endothelial cells (1), where the transcellular route is the main route of vesicle traffic, especially in capillaries with a continuous endothelium like those of skeletal and cardiac muscle, and brain. Transcytosis is also observed in many other types of cells, such as the transport of IgG from the lumen of the intestine to the perivascular space in the newborn rat (2), and the transport of IgA from the vascular front to the bile capillary front by hepatocytes (3,4).
KeywordsEndothelial Cell Insulin Receptor Phorbol Ester Aortic Endothelial Cell Insulin Binding
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