Insulin-Like Growth Factors and Their Receptors in the Pituitary and Hypothalamus

  • Ron G. Rosenfeld
  • Andrew R. Hoffman


The somatomedins, or insulin-like growth factors (IGFs), constitute a family of peptide hormones which are growth hormone dependent, possess insulin-like activity and have mitogenic activity in a wide variety of cell lines1. Two human somatomedins have been purified and sequenced: IGF-I has a molecular weight of 7649, and consists of 70 amino acids, while IGF-II has a molecular weight of 7471, with 67 amino acids2,3. A rat equivalent of IGF-II, termed multiplication stimulating activity (MSA), has also been purified and sequenced; it differs from human IGF-II in four of the 67 amino acid positions4. The sequences of cDNAs encoding for human prepro-IGF-I and -II have been elucidated, and the respective 130 and 180 amino acid precursors predicted5,6. IGF-II has been mapped to the short arm of chromosome 11, tightly linked to both the insulin gene and the c-Ha-rasl proto-oncogene7. IGF-I maps to chromosome 12, which is evolutionarily related to chromosome 11, and carries the gene for the c-Ki-ras2 proto-oncogene8.


Pituitary Cell Growth Hormone Secretion Growth Hormone Release Human Pituitary Adenoma Stimulate Growth Hormone Release 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Ron G. Rosenfeld
    • 1
  • Andrew R. Hoffman
    • 1
  1. 1.Departments of Pediatrics and MedicineStanford University Medical CenterStanfordUSA

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