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Insulin-Like Growth Factors and Their Receptors in the Pituitary and Hypothalamus

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Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System

Abstract

The somatomedins, or insulin-like growth factors (IGFs), constitute a family of peptide hormones which are growth hormone dependent, possess insulin-like activity and have mitogenic activity in a wide variety of cell lines1. Two human somatomedins have been purified and sequenced: IGF-I has a molecular weight of 7649, and consists of 70 amino acids, while IGF-II has a molecular weight of 7471, with 67 amino acids2,3. A rat equivalent of IGF-II, termed multiplication stimulating activity (MSA), has also been purified and sequenced; it differs from human IGF-II in four of the 67 amino acid positions4. The sequences of cDNAs encoding for human prepro-IGF-I and -II have been elucidated, and the respective 130 and 180 amino acid precursors predicted5,6. IGF-II has been mapped to the short arm of chromosome 11, tightly linked to both the insulin gene and the c-Ha-rasl proto-oncogene7. IGF-I maps to chromosome 12, which is evolutionarily related to chromosome 11, and carries the gene for the c-Ki-ras2 proto-oncogene8.

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Authors and Affiliations

  1. Departments of Pediatrics and Medicine, Stanford University Medical Center, Stanford, California, USA

    Ron G. Rosenfeld & Andrew R. Hoffman

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  1. Ron G. Rosenfeld
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  2. Andrew R. Hoffman
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Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada  & M. Ian Phillips  & 

  2. Diabetes Branch, NIDDK, NIH, Bethesda, Maryland, USA

    Derek LeRoith

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© 1987 Plenum Press, New York

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Rosenfeld, R.G., Hoffman, A.R. (1987). Insulin-Like Growth Factors and Their Receptors in the Pituitary and Hypothalamus. In: Raizada, M.K., Phillips, M.I., LeRoith, D. (eds) Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5380-5_22

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  • DOI: https://doi.org/10.1007/978-1-4684-5380-5_22

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