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Receptors for Insulin and Insulin Related Peptides in the CNS: Studies of Localization in Rat Brain

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Abstract

The central nervous system (CNS) has traditionally been excluded as an insulin target tissue because glucose metabolism in the CNS seems to be unaffected by insulin. We have found that insulin and specific receptors for insulin are present in rodent brain although their physiologic role is unknown. Recent work in rats has shown that receptors for IGF-I and IGF-II are also present in the CNS.

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© 1987 Plenum Press, New York

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Hill, J.M., Lesniak, M.A., Rojeshi, M., Pert, C.B., Roth, J. (1987). Receptors for Insulin and Insulin Related Peptides in the CNS: Studies of Localization in Rat Brain. In: Raizada, M.K., Phillips, M.I., LeRoith, D. (eds) Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5380-5_20

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  • DOI: https://doi.org/10.1007/978-1-4684-5380-5_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5382-9

  • Online ISBN: 978-1-4684-5380-5

  • eBook Packages: Springer Book Archive

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