Insulin-Activated Phosphorylation on Tyrosine of a 15 Kilodalton Cytosolic Protein in 3T3-L1 Adipocytes

  • Michel Bernier
  • Susan C. Frost
  • Don M. Laird
  • Ronald A. Kohanski
  • M. Daniel Lane


The action of insulin is initiated by its interaction with the insulin receptor located on the surface of target cells (1). This interaction generates a signal, which when transmitted across the plasma membrane, is propagated and distributed to pleitropic control points of cellular metabolism. Modulation by insulin of flux through these controlled reactions is responsible for regulation of the major energy storage pathways in many cell types. In the adipocyte, glucose uptake, glycogenesis and lipogenesis are accelerated by insulin.


Insulin Receptor Phosphoamino Acid Tyrosyl Residue Phenyl Arsine Trivalent Arsenical 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Michel Bernier
    • 1
  • Susan C. Frost
    • 1
  • Don M. Laird
    • 1
  • Ronald A. Kohanski
    • 1
  • M. Daniel Lane
    • 1
  1. 1.Department of Biological ChemistryThe Johns Hopkins University School of MedicineBaltimoreUSA

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