Insulin-Like Growth Factor Receptors in the Brain

  • Denis G. Baskin
  • Nancy J. Bohannon
  • Dianne P. Figlewicz


A growing body of evidence now indicates that the central nervous system (CNS) is a target of peptides from the gut and pancreas. Insulin from the pancreatic islets, for example, enters the brain from the periphery and influences the physiology of the CNS (review by Baskin et al., 1987). The recent appreciation that insulin-like growth factors (IGF’s), peptides with insulin-like structure and biological activity, are also present in the CNS has stimulated a great deal of current interest in brain IGF’s and their possible functions in the CNS. The present article reviews the status of the IGF’s as regulatory peptides in the CNS, and emphasizes recent developments concerning the anatomical location of receptors for IGF’s in the brain.


Choroid Plexus Growth Hormone Secretion Median Eminence Quantitative Autoradiography Autoradiographic Image 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Denis G. Baskin
    • 1
    • 2
  • Nancy J. Bohannon
    • 1
    • 2
  • Dianne P. Figlewicz
    • 1
    • 2
  1. 1.Veterans Administration Medical CenterSeattleUSA
  2. 2.Departments of Medicine, Biological Structure, and PsychologyUniversity of WashingtonSeattleUSA

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