Structural Evidence for a Subtype of Insulin Receptor in the Central Nervous System

  • Kim A. Heidenreich


Since the discovery of insulin1 and insulin receptors2 in the brain in 1978, there has been an increasing number of investigations into the physiological role of insulin in the central nervous system (CNS). One area of CNS physiology affected by insulin is the regulation of feeding behavior and body weight. Chronic intracerebral ventricular infusion of insulin reduces food intake and body weight3, suggesting that insulin acts as a satiety factor in the CNS. Consistent with this notion is the report that Zucker rats carrying the fa gene have fewer brain insulin receptors4. Furthermore, insulin has been shown to directly alter the firing rate of glucose-sensitive neurons in the ventromedial and lateral hypothalamus5.


Sialic Acid Insulin Receptor Apparent Molecular Weight Insulin Binding Clonal Cell Line 


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Kim A. Heidenreich
    • 1
  1. 1.Department of Medicine; M-023EUniversity of California, San DiegoLa JollaUSA

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