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Translational Regulation in the Heat-Shock Response of Drosophila Cells

  • Susan Lindquist

Abstract

The heat-shock response has been the subject of intense investigation for several years. The speed of the induction, the magnitude of the response, and the reproducibility of the effect combine to make it an ideal system for investigating mechanisms of gene expression in a wide variety of organisms. In this chapter, I will review current knowledge of translational regulation in the response, focusing on the fruit fly Drosophila melanogaster for two reasons: First, the response of Drosophila cells is the strongest known example of differential gene expression regulated at the translational level. Second, more is known about heat-shock protein synthesis in this organism than in any other.

Keywords

Heat Shock Hsp70 Gene Translational Regulation Tissue Culture Cell Drosophila Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Susan Lindquist
    • 1
  1. 1.Department of Molecular Genetics and Cell BiologyUniversity of ChicagoChicagoUSA

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