Translational Regulation of Ribosomal Protein Gene Expression in Eukaryotes

  • Marcelo Jacobs-Lorena
  • Howard M. Fried

Abstract

The ribosome has attracted our attention not only because of its remarkable ability to polymerize amino acids under the guidance of ribonucleotide triplets, but also because of the relationship between synthesis and assembly of its constituents. In eukaryotes, the ribosome is assembled from four RNA molecules and between 70 and 80 proteins.1 These various components are distributed over two subunits, one comprising roughly one third and the other two thirds of the total ribosome mass. Accumulation of these components, which may represent as much as 85% of a cell’s RNA and 15% of its protein, is an extremely efficient process. How is it that all the macromolecules in such a diverse collection exhibit similar properties of synthesis or accumulation to fulfill the exacting demands of their association? It is becoming increasingly evident that in eukaryotes, posttranscriptional regulatory mechanisms play a role in bringing about and maintaining the appropriate accumulation of ribosomal proteins. Fittingly, regulation of the translation of ribosomal protein messenger RNAs (mRNAs) appears to be one such mechanism. This chapter constitutes a summary of our current knowledge of these mechanisms along with some thoughts for future investigation.

Keywords

Ribosomal Protein Translational Efficiency Translational Regulation Ribosomal Protein Gene rRNA Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Marcelo Jacobs-Lorena
    • 1
  • Howard M. Fried
    • 2
  1. 1.Department of Developmental Genetics and AnatomySchool of Medicine, Case Western Reserve UniversityClevelandUSA
  2. 2.Department of Biochemistry and NutritionUniversity of North Carolina at Chapel HillChapel HillUSA

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