Abstract
For many years, it was believed that the regulation of gene expression in prokaryotes occurs only at the transcriptional level. However, many results in the last ten years demonstrate that the process of translation is an important step for the regulation of gene expression and can affect the termination of transcription through polarity or attenuation of transcription. The translation step itself can also be regulated. The first example of translational regulation was found in RNA phages 1 and is still being studied.2 Other examples of genes regulated at the translational level have been discovered, particularly in the case of genes that code for proteins that bind nucleic acids. Examples of these include gene 32 of phage T4,3 the ribosomal protein operons,4 the initiation factor 3 (IF3) gene,5 and the threonyl-transfer RNA (tRNA) synthetase reported herein.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Lodish, H. F., Zinder, H. D., 1966, J. Mol. Biol. 19: 333–348.
Carey, J., Lowary, P. T., Uhlenbeck, O. C., 1983, Biochemistry 22: 4723–4730.
Von Hippel, P. H., Kowalczykowsky, S. C., Lomberg, N., Newport, J. W., Paul, L. S., Stormo, G. D., Gold, L., 1982, J. Mol. Biol. 162: 795–818.
Nomura, M., Gourse, R., Baughman, G., 1984, Annu. Rev. Biochem. 53: 75–117.
Butler, J. S., Springer, M., Dondon, J., Graffe, M., Grunberg-Manago, M., 1986, J. Mol. Biol. 192: 767–780.
Baughman, G., Nomura, M., 1984, Proc. Natl. Acad. Sci. U.S.A. 81: 5389–5393.
Friesen, J. D., Tropack, M., An, G., 1983, Cell 32: 361–369.
Hennecke, H., Bock, A., Thomale, J., Nass, G., 1977, J. Bacteriol. 131: 949–950.
Plumbridge, J. A., Springer, M., Graffe, M., Goursot, R., Grunberg-Manago, M., 1980, Gene 11: 33–42.
Mayaux, J. F., Fayat, G., Fromant, M., Springer, M., Grunberg-Manago, M., Blanquet, S., 1983, Proc. Natl. Acad. Sci. U.S.A. 80: 6152–6156.
Fayat, G., Mayaux, J. F., Sacerdot, C., Fromant, M., Springer, M., Grunberg-Manago, M., Blanquet, S., 1983, J. Mol. Biol. 171: 239–261.
Archibold, E. R., Williams, L. S., 1972, J. Bacteriol. 109: 1020–1206.
Neidhardt, F. C., Bloch, P. L., Pedersen, S., Reeh, S., 1977, J. Bacteriol. 129: 378–387.
Plumbridge, J. A., Springer, M., 1982, J. Bacteriol. 152: 661–668.
Lestienne, P., Plumbridge, J. A., Grunberg-Manago, M., Blanquet, S., 1984, J. Biol. Chem. 259: 5232–5237.
Springer, M., Plumbridge, J. A., Butler, J. S., Graffe, M., Dondon, J., Mayaux, J. F., Fayat, G., Lestienne, P., Blanquet, S., Grunberg-Manago, M., 1985, J. Mol. Biol. 185: 93–104.
Butler, J. S., Springer, M., Dondon, J., Grunberg-Manago, M., 1986, J. Bacteriol. 165: 198–203.
Springer, M., Graffe, M., Butler, J. S., Grunberg-Manago, M., 1986, Proc. Natl. Acad. Sci. U.S.A. 83: 4384–4388.
Kisselev, L. L., 1985, Prog. Nucleic Acids Res. Mol. Biol. 32: 237–266.
Karam, J., Gold, L., Singer, B., Dawson, M., 1981, Proc. Natl. Acad. Sci. U.S.A. 78: 4669–4673.
Miller, J. H., 1972, in: Experiments in Molecular Genetics, pp. 352 - 355, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Springer, M., Grunberg-Manago, M. (1987). Escherichia coli Threonyl-Transfer RNA Synthetase as a Model System to Study Translational Autoregulation in Prokaryotes. In: Ilan, J. (eds) Translational Regulation of Gene Expression. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5365-2_3
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5365-2_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5367-6
Online ISBN: 978-1-4684-5365-2
eBook Packages: Springer Book Archive