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Translational Control of Transcription Termination in Prokaryotes

  • Chapter
Translational Regulation of Gene Expression

Abstract

At this time, the most widely recognized form of translational control of gene expression in prokaryotes is attenuation. Attenuation can be broadly defined as the translational control of transcription termination at a site (the attenuator) preceding the first structural gene of an operon. Attenuation was originally discovered in 1974 by Yanofsky and co-workers as a regulatory mechanism involved in the control of the tryptophan operon.1–3 Since that time, attenuation has been demonstrated in the regulation of the biosynthesis of several other amino acids, including isoleucine and valine, the ilvGMEDA and ilvBN operons4–7; threonine, the thrABC operon8; leucine, the leuABCD operon9; histidine, the hisGDCBHAFIE operon10,11; and phenylalanine, the pheA operon.12

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Author information

Authors and Affiliations

  1. Department of Microbiology and Molecular Genetics, University of California, Irvine, California, 92717, USA

    G. Wesley Hatfield

  2. American Biogenetics Corporation, Irvine, California, 92715, USA

    Janice A. Sharp

Authors
  1. G. Wesley Hatfield
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  2. Janice A. Sharp
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Editors and Affiliations

  1. Department of Developmental Genetics and Anatomy, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA

    Joseph Ilan

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© 1987 Plenum Press, New York

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Hatfield, G.W., Sharp, J.A. (1987). Translational Control of Transcription Termination in Prokaryotes. In: Ilan, J. (eds) Translational Regulation of Gene Expression. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5365-2_21

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  • DOI: https://doi.org/10.1007/978-1-4684-5365-2_21

  • Publisher Name: Springer, Boston, MA

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