Bacterial Phosphodiesterases (Phospholipases C and D)

  • Moseley Waite
Part of the Handbook of Lipid Research book series (HLRE, volume 5)


The bacterial phosphodiesterases differ from the acyl hydrolase covered in Chapter 2 in that many enzymes of this class are secreted from the cell in a soluble form, a characteristic that has facilitated their purification and characterization. In general, these enzymes attack cellular membranes and either directly or indirectly are involved in cell killing and tissue damage in host organism. Because of their involvement in pathogenesis, they were often identified initially as a toxin before their catalytic function was defined. Indeed, much of the initial interest in bacterial phospholipases was generated by investigators seeking to minimize the effects of bacterial infections.


Culture Filtrate Phosphatidic Acid Hemolytic Activity Broad Substrate Specificity Guanidinium Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Moseley Waite
    • 1
  1. 1.Bowman Gray School of MedicineWake Forest UniversityWinston-SalemUSA

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