Role of D1 and D2 Dopamine Receptors in the Mammalian Striatum: Electrophysiological Studies and Functional Implications
Pharmacological, biochemical, and anatomical studies have indicated that at least two receptors for dopamine (D1 and D2) are present in mammalian CNS (Creese et al., 1983; Stoof and Kebabian, 1984). D1 receptors are associated with the stimulation of adenylate cyclase, while D2 receptors mediate either the inhibition of adenylate cyclase or are unlinked with this enzyme. Although the pharmacological evidence in favor of this receptor heterogeneity is strong, the physiological and clinical implications of these receptor classifications are not fully clarified.
KeywordsAdenylate Cyclase Dopaminergic Agonist Caudate Neuron Electro Physiological Membrane Rectification
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