Role of D1 and D2 Dopamine Receptors in the Mammalian Striatum: Electrophysiological Studies and Functional Implications

  • Paolo Calabresi
  • Nicola Mercuri
  • Paolo Stanzione
  • Giorgio Bernardi
Conference paper
Part of the Advances in Behavioral Biology book series (ABBI, volume 32)

Abstract

Pharmacological, biochemical, and anatomical studies have indicated that at least two receptors for dopamine (D1 and D2) are present in mammalian CNS (Creese et al., 1983; Stoof and Kebabian, 1984). D1 receptors are associated with the stimulation of adenylate cyclase, while D2 receptors mediate either the inhibition of adenylate cyclase or are unlinked with this enzyme. Although the pharmacological evidence in favor of this receptor heterogeneity is strong, the physiological and clinical implications of these receptor classifications are not fully clarified.

Keywords

Dopamine Hull Catecholamine Haloperidol Bromocriptine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arnt, J. and Hytell, J., 1984, Differential inhibition by dopamine D-1 D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions, Eur, J. Pharmacol., 102:349.CrossRefGoogle Scholar
  2. Arnt, J. and Hyttel, J., 1986, Behavioural differentiation between effects elicited at dopamine D1 and D2 receptors in rats, Clinical Neuropharmacol., 9(s6):17.Google Scholar
  3. Bernardi, G., Marciani, M.G., Morocutti, C., Pavone, F., and Stanzione, P., 1978, The action of dopamine on rat caudate neurons intracellularly recorded, [Neurosci. Lett., 8:235PubMedCrossRefGoogle Scholar
  4. Bernardi, G., Calabresi, P., Mercuri, N. and Stanzione, P., 1984, Dopamine decreases the amplitude of excitatory post-synaptic potentials in rat striatal neurons, in “The Basal Ganglia,” McKenzie, J.S. Kemm, R.E. and Wilcock, L.N., eds., Plenum Press, New York.Google Scholar
  5. Calabresi, P., Mercuri, N., Stefani, A., Stanzione, P. and Bernardi, G., 1986, Action of dopamine and of dopaminergic agonists on rat striatal neurons: an intracellular study “in vitro,” Neurosci. Lett., s26:316.Google Scholar
  6. Calabresi, P., Mercuri, N., Stanzione, P., Stefani, A., and Bernardi, G., 1987, Intracellular studies on the dopamine induced firing inhibition: evidence for D1 receptor involvement, Neurosci. in press.Google Scholar
  7. Creese, I., Sibley, D.R., Hamblin, N.W. and Leff, S.E., 1983, The classification of dopamine receptors: relationship to radioligand binding, Ann. Rev. Neurosci., 6:43.PubMedCrossRefGoogle Scholar
  8. Iorio, L.C., Barnett, A., Leitz, F.H., Honser, V.P., and Kordube, C.A., 1983, SCH 23390, a potential benzazepine anti-psychotic with unique interactions on dopaminergic system, J. Pharmacol. Exp. Ther., 226:462.PubMedGoogle Scholar
  9. Hahn, R.A., Wardell, J.R., Saran, H.M., and Ridley, P.T., 1982, Characterization of the peripheral and central effects of SKF 82526, a novel dopaminergic receptor agonist, J. Pharmacol. Exp, Ther., 223:305.Google Scholar
  10. Herrling, P.L. and Hull, C.D., 1980, Iontophoretically applied dopamine depolarizes and hyperpolarizes the membrane of cat caudate neurons, Brain Res., 192:441.PubMedCrossRefGoogle Scholar
  11. Hyttel, J. 1983, SCH 23390: the first selective dopamine D1 antagonist, Eur. J. Pharmacol., 91:153.PubMedCrossRefGoogle Scholar
  12. Kebabian, J.W., Agui, T., Van Oene, J.C., Shigematsu, K., and Saavedra, J.M., 1986, The D1 receptor: new perspectives, Trends in Pharmacol. Sci., 7:96.CrossRefGoogle Scholar
  13. Mercuri, N., Bernardi, G., Calabresi, P., Cotugno, A., Levi, G. and Stanzione, P., 1985, Dopamine decreases cell excitability in rat striatal neurons by pre- and post-synaptic mechanisms, Brain Res., 358:110.PubMedCrossRefGoogle Scholar
  14. Molloy, A.G. and Waddington, J.L., 1985, Sniffing, rearing and locomotor response to the D1 dopamine agonist R-SKF 38393 and to apomorphine: differential interactions with the selective D1 and D2 antagonists SCH 23390 and metaclopramide, Eur. J. Pharmacol., 108:305.PubMedCrossRefGoogle Scholar
  15. Stoof, J.C and Kebabian, J.W., 1984, Two dopamine receptors: biochemistry, physiology and pharmacology, Life Sci. 35:2281.PubMedCrossRefGoogle Scholar
  16. Traub, M., Reches, A., Wagner, H.R. and Fahn, S., 1986, Reserpine induced up-regulation of dopamine D2 receptors in the rat striatum is enhanced by denervation but not by chronic receptor blockade, Neurosci. Letters, 70:245.CrossRefGoogle Scholar
  17. Waddington, J.L., Molloy, A.C, O’Boyle, K.M. and Moshurono, M., 1986, Motor consequences of D1 dopamine receptor stimulation and blockade, Clinical Neuropharmacol., 9(s6):20.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Paolo Calabresi
    • 1
  • Nicola Mercuri
    • 1
  • Paolo Stanzione
    • 1
  • Giorgio Bernardi
    • 1
  1. 1.Clinica Neurologica IIUniversità di RomaRomeItaly

Personalised recommendations