Somatostatin-Dopamine Interactions in the Rat Striatum

  • J. M. Radke
  • M. T. Martin-Iverson
  • S. R. Vincent
Conference paper
Part of the Advances in Behavioral Biology book series (ABBI, volume 32)


An integration of the anatomical, physiological, and behavioural information available regarding the basal ganglia is essential for our understanding of this complex system. In this report, we will discuss the interactions of dopamine and somatostatin containing neurons in the basal ganglia. The emphasis will be on recent experiments examining the effects of cysteamine, a drug which selectively reduces somatostatin levels, on dopamine-induced behaviours in the rat. Furthermore, to provide a better understanding of the basis for these interactions, a review of the anatomy and physiology of the dopamine and somatostatin systems within the basal ganglia will also be presented.


Basal Ganglion Nucleus Accumbens Place Preference Conditioning Striatal Neuron Paradoxical Sleep 


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. M. Radke
    • 1
  • M. T. Martin-Iverson
    • 2
  • S. R. Vincent
    • 1
  1. 1.Division of Neurological SciencesUniversity of British ColumbiaVancouverCanada
  2. 2.Merck Sharpe & Dohme LaboratoriesNeuroscience Research CentreHarlow, EssexUK

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