Somatostatin-Dopamine Interactions in the Rat Striatum
An integration of the anatomical, physiological, and behavioural information available regarding the basal ganglia is essential for our understanding of this complex system. In this report, we will discuss the interactions of dopamine and somatostatin containing neurons in the basal ganglia. The emphasis will be on recent experiments examining the effects of cysteamine, a drug which selectively reduces somatostatin levels, on dopamine-induced behaviours in the rat. Furthermore, to provide a better understanding of the basis for these interactions, a review of the anatomy and physiology of the dopamine and somatostatin systems within the basal ganglia will also be presented.
KeywordsBasal Ganglion Nucleus Accumbens Place Preference Conditioning Striatal Neuron Paradoxical Sleep
Unable to display preview. Download preview PDF.
- Dalsgaard, C-. J., Vincent, S. R., Hökfelt, T., Wiesenfeld-Hallin, Z., Gustafsson, L., Elde, R., and Dockray, G. J., 1984, Effects of cysteamine on pain behaviour and on somatostatin- and substance P-like immunoreactivity in the substantia gelatinosa of the rat, European J. Pharmacol., 104:295.CrossRefGoogle Scholar
- Fibiger, H. C, and Phillips, A. G., 1986, Reward, motivation, cognition: psychobiology of mesotelencephalic dopamine systems, in: “ Handbook of Physiology: The Nervous System IV,” F.E. Bloom, V.B. Mountcastle, S.R. Geiger, eds., American Physiology Society, Maryland.Google Scholar
- Vécsei, L., Schwarzberg, H., and Telegdy, G., 1982, Comparative studies with linear and cyclic somatostatin on the self-stimulation of rats, Acta Physiol. Hung., 60:165.Google Scholar
- Vincent, S. R., Johansson, O., Skirboll, L., Hökfelt, T., 1982a, Coexistence of somatostatin- and avian pancreatic polypeptide-like immunoreactivities in striatal neurons which are selectively stained for NADPH-diaphorase activity, in: “Regulatory Peptides: From Molecular Biology to Function,” E. Costa and M. Trabucchi, eds., Raven Press, New York.Google Scholar
- Vincent, S. R., Johansson, O., Hökfelt, T., Skirboll, L., Elde, R. P., Terenius, L., Kimmel, J., and Goldstein, M., 1983a, NADPH-diaphorase: A selective histochemical marker for striatal neurons containing both somatostatin- and avian pancreatic polypeptide (APP)-like immuno-reactivities, J. Comp. Neurol., 217:264.PubMedCrossRefGoogle Scholar