Somatostatin-Dopamine Interactions in the Rat Striatum

  • J. M. Radke
  • M. T. Martin-Iverson
  • S. R. Vincent
Conference paper
Part of the Advances in Behavioral Biology book series (ABBI, volume 32)


An integration of the anatomical, physiological, and behavioural information available regarding the basal ganglia is essential for our understanding of this complex system. In this report, we will discuss the interactions of dopamine and somatostatin containing neurons in the basal ganglia. The emphasis will be on recent experiments examining the effects of cysteamine, a drug which selectively reduces somatostatin levels, on dopamine-induced behaviours in the rat. Furthermore, to provide a better understanding of the basis for these interactions, a review of the anatomy and physiology of the dopamine and somatostatin systems within the basal ganglia will also be presented.


Basal Ganglion Nucleus Accumbens Place Preference Conditioning Striatal Neuron Paradoxical Sleep 
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  1. Agren, H., and Lundqvist, G., 1984, Low levels of somatostatin in human CSF mark depressive episodes, Psychoneuroendocr., 9:233.CrossRefGoogle Scholar
  2. Araki, M., McGeer, P. L., and McGeer, E. G., 1985, Differential effect of kainic acid on somatostatin, GABAergic, and cholinergic neurons in the rat striatum, Neurosci. Lett., 53:197.PubMedCrossRefGoogle Scholar
  3. Arluison M., Dietl, M., and Thibault, J., 1984, Ultrastructural morphology of dopaminergic nerve terminals and synapses in the striatum of the rat using tyrosine hydroxylase immunocytochemistry: a topographical study, Brain Res. Bull., 13:269.PubMedCrossRefGoogle Scholar
  4. Aronin, N., Cooper, P. E., Lorenz, L. J., Bird, E. D., Sagar, S. M., Leeman, S. E., and Martin, J. B., 1983, Somatostatin is increased in the basal ganglia in Huntington’s disease, Ann. Neurol., 13:519.PubMedCrossRefGoogle Scholar
  5. Barbeau, A., 1962, The pathogenesis of Parkinson’s disease: a new hypothesis, Canad. Med. Ass. J., 87:802.PubMedGoogle Scholar
  6. Beal, M. F., Bird, E. D., Langlais, P. J., and Martin, J. B., 1984, Somatostatin is increased in the nucleus accumbens in Huntington’s disease, Neurology, 34:663.PubMedGoogle Scholar
  7. Beal, M. F., Chattha, G. K., and Martin, J. B., 1962A, A comparison of regional somatostatin and neuropeptide Y distribution in the rat striatum and brain, Brain Res., 377:240.CrossRefGoogle Scholar
  8. Beal, M. F., Domesick, V. B., and Martin, J. B., 1983, Regional somatostatin distribution in the rat striatum, Brain Res., 278:103.PubMedCrossRefGoogle Scholar
  9. Beal, M. F., Domesick, V. B., and Martin, J. B., 1985, Effects of lesions in the amygdala and periventricular hypothalamus on striatal somatostatin-like immunoreactivity, Brain Res., 330:309.PubMedCrossRefGoogle Scholar
  10. Beal, M. F., Frank, R. C, Ellison, D. W., and Martin, J. B., 1986b, The effects of neuropeptide Y on striatal catecholamines, Neurosci. Lett., 71:118.PubMedCrossRefGoogle Scholar
  11. Beal, M. F., and Martin, J. B., 1983, Effects of lesions on somatostatin-like immunoreactivity in the rat striatum, Brain Res., 266:67.PubMedCrossRefGoogle Scholar
  12. Beal, M. F., and Martin, J. B., 1984a, The effect of somatostatin on striatal catecholamines, Neurosci. Lett., 44:271.PubMedCrossRefGoogle Scholar
  13. Beal, M. F., and Martin, J. B., 1984b, Depletion of striatal somatostatin by local cysteamine injection, Brain Res., 308:319.PubMedCrossRefGoogle Scholar
  14. Beal, M. F., and Martin, J. B., 1984c, Effects of neuroleptic drugs on brain somatostatin-like immunoreactivity, Neurosci. Lett., 47:125.PubMedCrossRefGoogle Scholar
  15. Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., and Guillemin, R., 1973, Hypothalamic peptide that inhibits the secretion of immunoreactive pituatary growth hormone, Science, 179:77.PubMedCrossRefGoogle Scholar
  16. Brown, M. R., Fisher, L. A., Sawchenko, P. E., Swanson, L. W., and Vale, W. W., 1983, Biological effects of cysteamine: relationship to somatostatin depletion, Regulat. Peptides, 5:163.CrossRefGoogle Scholar
  17. Brownstein, M., Arimura, A., Sato, H., Schally, A. V., and Kizer, J., 1975, The regional distribution of somatostatin in the rat brain, Endocrinol., 96: 1456.CrossRefGoogle Scholar
  18. Burke, R. E., and Fahn, S., 1983, Studies of somatostatin-induced barrel rotation in rats, [Reg. Peptides, 7:207.CrossRefGoogle Scholar
  19. Chesselet, M-. F., and Reisine, T. D., 1983, Somatostatin regulates dopamine release in rat striatal slices and cat caudate nuclei, J. Neurosci., 3:232.PubMedGoogle Scholar
  20. Chneiweiss, H., Glowinski, J., and Premont, J., 1985, Modulation by monoamines of somatostatin-sensitive adenylate cyclase on neuronal and glia cells from mouse brain in primary culture, J. Neurochem., 44: 1825.PubMedCrossRefGoogle Scholar
  21. Crowley, W. R., and Terry, L. C., 1985, Biochemical mapping of somatostatinergic systems in the rat brain: effects of periventricular hypothalamic and medial basal amygdaloid lesions on somatostatin-like immunoreactivity in discrete brain nuclei, Brain Res., 200:283.CrossRefGoogle Scholar
  22. Dalsgaard, C-. J., Vincent, S. R., Hökfelt, T., Wiesenfeld-Hallin, Z., Gustafsson, L., Elde, R., and Dockray, G. J., 1984, Effects of cysteamine on pain behaviour and on somatostatin- and substance P-like immunoreactivity in the substantia gelatinosa of the rat, European J. Pharmacol., 104:295.CrossRefGoogle Scholar
  23. Danguir, J., 1986, Intracerebroventricular infusion of somatostatin selectively increases paradoxical sleep in rats, Brain Res., 367:26.PubMedCrossRefGoogle Scholar
  24. Davies, P., Katzman, R., and Terry, R. D., 1980, Reduced somatostatin like immunoreactivity in cerbral cortex from cases of Alzheimer’s disease and Alzheimer’s senile dementia, Nature, 288:279.PubMedCrossRefGoogle Scholar
  25. Dawbarn, D., DeQuit, M. E., and Emson, P. C., 1985, Survival of basal ganglia neuropeptide Y-somatostatin neurons in Huntington’s disease, Brain Res., 340:251.PubMedCrossRefGoogle Scholar
  26. DiFiglia, M., and Aronin, N., 1982, Ultrastructural features of immunoreactive somatostatin neurons in the rat caudate nucleus, J. Neurosci., 2:1267.PubMedGoogle Scholar
  27. DiScala, G., Martin-Iverson, M. T., Phillips, A. G., and Fibiger, H. C., 1985, The effects of progabide (SL 76002) on locomotor activity and conditioned place preference induced by d-amphetamine, Europ. J. Pharmacol., 107:271.CrossRefGoogle Scholar
  28. Epelbaum, J., Ruberg, M., Moyse, M., Javoy-Agid, F., Dubois, B., and Agid, Y., 1983, Somatostatin and dementia in Parkinson’s disease, Brain Res., 278: 376.PubMedCrossRefGoogle Scholar
  29. Ferrante, R. J., Kowall, N. W., Beal, M. F., Richardson, E. P., Bird, E. D., and Martin, J. B., 1985, Selective sparing of a class of striatal neurons in Huntington’s disease, Science, 230:561.PubMedCrossRefGoogle Scholar
  30. Fibiger, H. C, and Phillips, A. G., 1986, Reward, motivation, cognition: psychobiology of mesotelencephalic dopamine systems, in: “ Handbook of Physiology: The Nervous System IV,” F.E. Bloom, V.B. Mountcastle, S.R. Geiger, eds., American Physiology Society, Maryland.Google Scholar
  31. Finley, J. C. W., Maderdrut, J. L., Roger, L. J., and Petrusz, P., 1981, The immunocytochemical localization of somatostatin-containing neurons in the rat central nervous system, Neurosci., 6: 2173.CrossRefGoogle Scholar
  32. Freund, T., Powell, J., and Smith, A., 1984, Tyrosine-hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines, Neurosci., 13:1189.CrossRefGoogle Scholar
  33. Fuxe, K., Hökfelt, T., Eneroth, T., Gustafsson, J-. A. and Skett, P., 1977, Prolactin-like immuno-reactivity: localization in nerve terminals of rat hypothalamus, Science., 196:889.CrossRefGoogle Scholar
  34. Garcia-Sevilla, J. A., Magnusson, T., and Carlsson, A., 1978, Effect of intracerebroventricularly administered somatostatin on brain monoamine turnover, Brain Res., 155:159.PubMedCrossRefGoogle Scholar
  35. Havlicek, V., Rezek, M., and Friesen, H., 1976, Somatostatin and thyrotropin releasing hormone: Central effect on sleep and motor system, Pharmacol. Biochem. Behav., 4:455.PubMedCrossRefGoogle Scholar
  36. Herchl, R., Havlicek, V., Rezek, M., and Kroeger, E., 1977, Cerebroventricular administration of somatostatin (SRIF): effects on central levels of cyclic AMP, Life Sci., 20:821.PubMedCrossRefGoogle Scholar
  37. Higuchi, T., Sikand, G. S., Kato, N., Wada, J. A., and Friesen, H. G., 1983, Profound suppression of kindling seizures by cysteamine: possible role of somatostatin in kindled seizures, Brain Res., 288: 359.PubMedCrossRefGoogle Scholar
  38. Jacobs, L. S., and Lorenson, M. Y., 1984, Cysteamine inhibition of prolactin immunoassayability and secretion: studies with aminothiols and other analogs, Endocrinol., 115:1210.CrossRefGoogle Scholar
  39. Johansson, O., Hökfelt, T., and Elde, R. P., 1984, Immunohistochemical distribution of somatostatin-like immunoreactivity in the central nervous system of the adult rat, Neurosci., 13:265.CrossRefGoogle Scholar
  40. Kelly, P. H., Seviour, P. W., and Iversen, S. D., 1975, Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum, Brain Res., 94:507.PubMedCrossRefGoogle Scholar
  41. Kimura, H., McGeer, P. L., Peng, F., and McGeer, E. G., 1980, Choline acetylcholinesterase-containing neurons in rodent brain demonstrated by immunohistochemistry, Science., 208:1057.PubMedCrossRefGoogle Scholar
  42. Kobayashi, R. M., Brown, M., and Vale, W., 1977, Regional distribution of neurotensin and somatostatin in rat brain, Brain Res., 126:584.PubMedCrossRefGoogle Scholar
  43. Martin-Iverson, M. T., Ortmann, R., and Fibiger, H. C., 1985, Place preference conditioning with methylphenidate and nomifensine, Brain Res., 332: 59.PubMedCrossRefGoogle Scholar
  44. Martin-Iverson, M. T., Radke, J. M., and Vincent, S. R., 1986, The effects of cysteamine on dopamine-mediated behaviours : evidence for dopamine-somatostatin interactions in the striatum, Pharmacol. Biochem. Behav., 24:1707.PubMedCrossRefGoogle Scholar
  45. McGeer, P. L., Boulding, J. E., Gibson, W. C, Foulkes, R. G., 1961, Drug-induced extrapyramidal reactions J. Amer. Med. Ass., 177:665.CrossRefGoogle Scholar
  46. Millard, W. J., Sagar, S. M., Landis, D. M. D., Martin, J. B., and Badger, T. M., 1982, Cysteamine: a potent and specific depletor of pituatary prolactin, Science, 217:452.PubMedCrossRefGoogle Scholar
  47. Moser, A., Reavill, C., Jenner, P., Marsden, C. D., and Cramer, H., 1986, Effects of somatostatin on dopamine sensitive cyclase activity in the caudate-putamen of the rat, Exp. Brain Res., 62: 567.PubMedCrossRefGoogle Scholar
  48. Nemeroff, C. B., Youngblood, W. W., Manberg, P. J., Prange, A. J., and Kizer, J. S., 1983, Regional brain concentrations of neuropeptides in Huntington’s chorea and schizophrenia, Science, 221:972.PubMedCrossRefGoogle Scholar
  49. Palkovits, M., Kobayashi, R., Brown, M., and Vale, W., 1980, Changes in hypothalamic, limbic, and extrapyramidal somatostatin levels following various hypothalamic transections in the rat, Brain Res., 195:499.PubMedCrossRefGoogle Scholar
  50. Palkovits, M., Brownstein, M. J., Eiden, L. E., Beinfeld, M. C., Russell, J., Arimura, A., and Szabo, S., 1982, Selective depletion of somatostatin in rat brain by cysteamine, Brain Res., 240:178.PubMedCrossRefGoogle Scholar
  51. Pickel, V. M., Beckley, S. C., Joh, T. H., and Reis, D. J., 1981, Ultrastructural immunocytochemical localization of tyrosine hydroxylase in the neostriatum, Brain Res., 225:373.PubMedCrossRefGoogle Scholar
  52. Plotnikoff, N. P., Kastin, A. J., and Schally, A. V., 1974, Growth hormone release inhibiting hormone, Neuropharmacological studies, Pharmacol. Biochem. Behav., 2:693.PubMedCrossRefGoogle Scholar
  53. Reichlin, S., and Bollinger-Gruber, J. A., 1985, Pantethine, a cysteamine precursor, depletes immunoreactive somatostatin and prolactin in the rat. Endocrinol., 117:492.CrossRefGoogle Scholar
  54. Reubi, J. C, and Maurier, R., 1985, Autoradiographic mapping of somatostatin receptors in the rat central nervous system and pituatary, Neurosci., 15:1183.CrossRefGoogle Scholar
  55. Rezek, M., Havelicek, V., Hughes, K. R., and Friesen, H., 1976, Cortical administration of somatostatin (SRIF): Effect on sleep and motor behavior, Pharmac. Biochem. Behav., 5:73.CrossRefGoogle Scholar
  56. Rezek, M., Havlicek, V., Leybin, L., Pinsky, C., Kroeger, E. A., Hughes, K. R., and H. Friesen, H., 1977, Neostriatal administration of somatostatin: differential effect of small and large doses on behavior and motor control, Can. J. Physiol. Pharmacol., 55:234.PubMedCrossRefGoogle Scholar
  57. Rubinow, D. R., Gold, P. W., Post, R. M., and Ballinger, J. C., 1985, CSF somatostatin in affective illness and normal volunteers, Prog. Neuro-Psychpharmacol. & Biol. Psychiat., 9:393.CrossRefGoogle Scholar
  58. Sagar, S. M., Landry, D., Millard, W. J., Badger, T. M., Arnold, M. A., and Martin, J. B., 1982, Depletion of somatostatin-like immunoreactivity in the rat central nervous system by cysteamine, J. Neurosci., 2:225.PubMedGoogle Scholar
  59. Shults, C., Steardo, C., Barone, P., Mohr, E., Juncos, J., Serrati, C., Fedio, P., Tamminga, C. A., and Chase, T. N., 1986, Huntington’s disease: Effects of cysteamine, a somatostatin-depleting agent, Neurology, 36:1099.PubMedGoogle Scholar
  60. Spyraki, C., Fibiger, H. C., and Phillips, A. G., 1983, Dopaminergic substrates of amphetamine-induced place preference conditioning, Brain Res., 253:185.CrossRefGoogle Scholar
  61. Starr, M. S., 1982, Influence of peptides on 3H-dopamine release from superfused rat striatal slices, Neurochem. Internat., 4:233.CrossRefGoogle Scholar
  62. Szabo, S. and Reichlin, S., 1981, Somatostatin in rat tissues is depleted by cysteamine administration, Endocrinol., 109:2255.CrossRefGoogle Scholar
  63. Takagi, H., Somogyi, P., Somogyi, J., and Smith, A. D., 1983, Fine structural studies on a type of somatostatin-immunoreactive neuron and its synaptic connections in the rat neostriatum: a correlated light and electron microscopic study, J. Comp. Neurol., 214:1.PubMedCrossRefGoogle Scholar
  64. Vécsei, L., Bollök, I., and Telegdy, G., 1983, Comparative studies with cyclic and linear somatostatin on active avoidance behaviour and open-field activity in rats, Acta Physiol. Hung., 61:43.PubMedGoogle Scholar
  65. Vécsei, L., Király, C., Bollók, I., Nagy, A., Varga, J., Penke, B., and Telegdy, G., 1984, Comparative studies with somatostatin and cysteamine in different behavioral tests on rats, Pharmacol. Biochem. Behav., 21:833.PubMedCrossRefGoogle Scholar
  66. Vécsei, L., Schwarzberg, H., and Telegdy, G., 1982, Comparative studies with linear and cyclic somatostatin on the self-stimulation of rats, Acta Physiol. Hung., 60:165.Google Scholar
  67. Vécsei, L., Bollók, I., Penke, B., and Telegdy, G., 1986, Somatostatin and (D-Trp8, D-Cys14)-somatostatin delay extinction and reverse electroconvulsive shock induced amnesia in rats, Psychoneuroendocr., 11:111.CrossRefGoogle Scholar
  68. Vincent, S. R., and Johansson, O., 1983, Striatal neurons containing both somatostatin- and avian pancreatic polypeptide (APP)-like immuno-reactivities and NADPH-diaphorase activity: a light and electron microscopic study, J. Comp. Neurol., 217:264.PubMedCrossRefGoogle Scholar
  69. Vincent, S. R., Johansson, O., Skirboll, L., Hökfelt, T., 1982a, Coexistence of somatostatin- and avian pancreatic polypeptide-like immunoreactivities in striatal neurons which are selectively stained for NADPH-diaphorase activity, in: “Regulatory Peptides: From Molecular Biology to Function,” E. Costa and M. Trabucchi, eds., Raven Press, New York.Google Scholar
  70. Vincent, S. R., Johansson, O., Hökfelt, T., Skirboll, L., Elde, R. P., Terenius, L., Kimmel, J., and Goldstein, M., 1983a, NADPH-diaphorase: A selective histochemical marker for striatal neurons containing both somatostatin- and avian pancreatic polypeptide (APP)-like immuno-reactivities, J. Comp. Neurol., 217:264.PubMedCrossRefGoogle Scholar
  71. Vincent, S. R., Mcintosh, C. H. S., Buchan, A. M. J. and Brown, J. C., 1985, Central somatostatin systems revealed with monoclonal antibodies, J. Comp. Neurol., 238:169.PubMedCrossRefGoogle Scholar
  72. Vincent, S. R., Skirboll, L., Hökfelt, T., Johansson, O., Lundberg, J. M., Elde, R. P., Terenius, L., and Kimmel, J., 1982b, Coexistence of somatostatin- and avian pancreatic polypeptide (APP)-like immunoreactivity in some forebrain neurons, Neurosci., 7:439.CrossRefGoogle Scholar
  73. Vincent, S. R., Staines, W. A., and Fibiger, H. C., 1983b, Histochemical demonstration of separate populations of somatostatin and cholinergic neurons in the rat striatum, Neurosci. Lett., 35: 111.PubMedCrossRefGoogle Scholar
  74. Wehrenberg, W. B., Benoit, R., Baird, A., and Guillemin, R., 1983, Inhibitory effects of cysteamine on neuroendocrine function, Regulat. Peptides, 6:137.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. M. Radke
    • 1
  • M. T. Martin-Iverson
    • 2
  • S. R. Vincent
    • 1
  1. 1.Division of Neurological SciencesUniversity of British ColumbiaVancouverCanada
  2. 2.Merck Sharpe & Dohme LaboratoriesNeuroscience Research CentreHarlow, EssexUK

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