Weaver—A Mutant Gene that Affects the Basal Ganglia

  • Suzanne Roffler-Tarlov
  • Ann M. Graybiel
Part of the Advances in Behavioral Biology book series (ABBI, volume 32)


Soon after evidence for a mesotelencephalic dopamine-containing pathway finally became unassailable, the dual nature of this projection was recognized (Anden et al. 1966; Ungerstedt, 1971). The two divisions of the path described by these investigators are: (1) the nigrostriatal system, which originates mainly in the dopamine-containing neurons of the substantia nigra’s pars compacta (cell group A9 of Dahlstrom and Fuxe, 1964) and innervates most of the caudoputamen, and (2) the mesolimbic system, which originates mainly in the dopamine-containing cells of the ventral tegmental area (cell groups A10 of Dahlstrom and Fuxe, 1964) and innervates the nucleus accumbens, most of the olfactory tubercle and the ventral part of the caudoputamen (Ungerstedt, 1971; Bjorklund and Lindvall, 1984; Fallon and Moore, 1978; Beckstead et al., 1979). The nigrostriatal and mesolimbic pathways are also separable on the basis of their other neural affiliations. The nigrostriatal system with its target the dorsal caudoputamen are associated with sensorimotor systems whereas the mesolimbic system and the ventral striatum are associated with limbic regions, a relationship clearly embedded in the name given to this pathway (Kelley et al., 1982; Heimer and Wilson, 1975; Graybiel and Ragsdale, 1979).


Granule Cell Nucleus Accumbens Ventral Tegmental Area Ventral Striatum Dopamine Concentration 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Suzanne Roffler-Tarlov
    • 1
  • Ann M. Graybiel
    • 2
  1. 1.Depts. of Neurology, Anatomy and Cellular BiologyTufts University School of Med.BostonUSA
  2. 2.Dept. of Brain and Cognitive SciencesMITCambridgeUSA

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