The Putamen Neuron: Activity and the Association of a Sensory Stimulus with Movement in the Monkey

  • Minoru Kimura
Part of the Advances in Behavioral Biology book series (ABBI, volume 32)


The putamen has been known to be involved in the neuronal process of voluntary movement mainly from the following two reasons (DeLong, 1981; Marsden, 1982). The first, damage to the striatum including the putamen results in movement disorders and sensori-motor deficits in both animals and man (Wilson, 1914; Denny-Brown, 1962; Denny-Brown and Yanagisawa, 1976; Ljungberg and Ungerstedt, 1976). The representatives of these in man are Parkinson’s disease and Huntington’s disease (Hornykiewicz, 1973). The second, modulation of neuronal activity in the putamen and globus pallidus has been demonstrated during learned body movement in the primate (Aldridge et al., 1980; Georgopoulos et al., 1983; Crutcher and DeLong, 1984; Anderson and Horak, 1985; Liles, 1985). In most of these studies, the movement related activity was reported not to precede the EMG activity in prime mover muscles. Therefore, it was suggested that the putamino-pallidal system did not play a major role in initiation of movement, but would be involved in the process of execution of movement (Aldridge et al, 1980; Georgopoulos et al., 1983; Crutcher and DeLong, 1984), facilitation of EMG activity (Anderson and Horak, 1985) or processing of somesthetic input during movement (Liles, 1985).


Globus Pallidus Sensory Stimulus Phasic Discharge Trigger Stimulus Pallidal Neuron 


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  1. Alexander,G.E. and DeLong, M.R., 1985, Microstimulation of the primate neostriatum. II. Somatotopic organization of striatal microexcitable zones and their relation to neuronal response properties. J. Neurophysiol., 53:1417.PubMedGoogle Scholar
  2. Aldridge, J.W., Anderson, R.J. and Murphy, J.T., 1980, The role of the basal ganglia in controlling a movement initiated by a visually presented cue. Brain Res., 192:3.PubMedCrossRefGoogle Scholar
  3. Anderson, M.E. and Horak, F.B., 1985, Influence of the globus pallidus on arm movements in monkeys. III. Timing of movement related information, J. Neurophysiol., 54:433.PubMedGoogle Scholar
  4. Crutcher, M.D. and DeLong, M.R., 1984, Single cell studies of the primate putamen. I. Functional organization, Exp. Brain Res., 53:233.PubMedCrossRefGoogle Scholar
  5. DeLong, M.R., 1981, Motor function of the basal ganglia, in: “Handbook of Physiology Vol. II”, Brookhart et al., eds., American Physiological Society ppl017–1061.Google Scholar
  6. Denny-Brown, D., 1962, in, “The Basal Ganglia and Their Relation to Didorders of Movement”, Oxford University Press, London.Google Scholar
  7. Denny-Brown, D. and Yanagisawa, N., 1976, The role of the basal ganglia in the initiation of movement, in, “The Basal Ganglia”, Yahr, M.D., ed., Res. Publ. Assoc. Nerv. Ment. Dis., 55: 115.Google Scholar
  8. Evarts, E.V., 1966, Pyramidal tract activity associated with a conditioned hand movement in the monkey, J. Neurophysiol., 29:1011.PubMedGoogle Scholar
  9. Georgopoulos, A.P., DeLong, M.R. and Crutcher, M.D., 1983, Relations between parameters of step tracking movements in single cell discharge in the globus pallidus and subthalamis nucleus of the behaving monkey. J. Neurosci., 3:1586.PubMedGoogle Scholar
  10. Graybiel, A.M. and Ragsdale, C.W., 1979, Fiber connections of the basal ganglia, in, “Development and chemical specificity of neurons”, eds. Cuenod.m, Kreutzberg, G.W. and Bloom, F.E. p239–283, Elsevier, Amsterdam.CrossRefGoogle Scholar
  11. Grofova, I. and Rinvik., 1970, An experimental electron microscopic study on the striatonigral projection in the cat, Exp. Brain Res., 11:249.PubMedCrossRefGoogle Scholar
  12. Hattori, T., Fibiger, H.C. and McGeer, P.L., 1975, Demonstration of a pallidonigral projection innervating dopaminergic neurons, J. Comp. Neurol., 162:487.PubMedCrossRefGoogle Scholar
  13. Hikosaka, O. and Sakamoto, M., 1986, Monkey caudate neurons related to the expectation of visual stimulus, Neurosci. Res., Suppl. 3: S82.Google Scholar
  14. Hornykiewicz, O., 1973 Dopamine in the basal ganglia: its role and therapoitic implications, Brit. Med. Bull., 29:172.PubMedGoogle Scholar
  15. Kimura, M., Rajkowski, J. and Evarts, E.V., 1984, Tonically discharging putamen neurons exhibits set dependent responses, Proc. Nat. Acad. Sci. U.S.A., 81:4998.CrossRefGoogle Scholar
  16. Kimura, M., 1986, The role of primate putamen neurons in the association of sensory stimuli with movement, Neurosci. Res., 3:436.PubMedCrossRefGoogle Scholar
  17. Kimura, M., Shimazaki, H. and Kato, M., 1987, Activity of primate putamen neurons which project to the globus pallidus during voluntary movement, Neurosci. Res. Suppl., (in press).Google Scholar
  18. Liles, S.L., 1985, Activity of neurons in putamen during active and passive movements of wrist, J. Neurophysiol., 53:217.PubMedGoogle Scholar
  19. Ljungberg, T. and Ungerstedt, O., 1976, Sensory inattention produced by 6-hydroxy-dopamine induced degeneration and ascending dopamine neurons in the brain, Exp. Neurol., 53: 585.PubMedCrossRefGoogle Scholar
  20. Marsden, C.D., 1982, The mysterious motor function of the basal ganglia: the Robert Wartenberg lecture, Neurology, 32:514.PubMedGoogle Scholar
  21. Rolls, E.T., Thorpe, S.J., Maddison, S., Roper-Hall, A., Puerto, A., and Perret, D., 1979, Activity of neurons in the neostriatum and related structures in the alert animal, in, “The Neostriatum”, Divac,I. and Oberg, R.G.E eds., Pergamon Press, Oxford, 163.Google Scholar
  22. Rolls, E.T., Thorpe, S.J. and Maddison, S.P., 1983, Responses of striatal neurons in the behaving monkey. 1. head of the caudate nucleus, Behav. Brain Res., 7:179.PubMedCrossRefGoogle Scholar
  23. Suzuki, H. and Azuma, M., 1976, A glass-insulated ‘elgiloy’ microelectrode for recording unit activity in chronic monkey experiments, Electroencephalogr. Clin. Neurophysiol., 41:93.PubMedCrossRefGoogle Scholar
  24. Teuber, H.L., 1976, Complex function of basal ganglia, in], The Basal Ganglia, Yahr, M.D., ed., Res. Publ. Assoc. Nerv. Ment. Dis., 55:151.Google Scholar
  25. Wilson, S.K.A., 1914, An experimental research into the anatomy and physiology of the corpus striatum, Brain, 36:427.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Minoru Kimura
    • 1
  1. 1.Department of PhysiologyJichi Medical SchoolTochigi-kenJapan

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