GABA and Enkephalin Immunoreactivity in Monkey Neostriatum
At the first IBAGS Symposium in Australia, we presented some of our work on the immunocytochemical localization of serotonin in the primate basal ganglia (Pasik et al., 1984). It was the only report at the meeting utilizing this technique. The program of this second symposium contains over a dozen such papers, bearing witness to the power of immunocytochemistry to unravel the intimate organization of the nervous system, particularly at the synaptic level. The advent of additional antibodies which recognize small molecules, such as neuroactive amino acids, together with the development of double labeling techniques at the ultrastructural level, have contributed greatly to the strength of the method. We have used such an antibody directed against GABA (Hodgson et al., 1985), and the localization of this compound together with leu-enkephalin (ENK) in the same section, to visualize specific immunoreactive elements in the neostriatum of the macaque monkey.
KeywordsGlobus Pallidus Symmetric Synapse Ferritin Particle Double Label Technique Neuroactive Amino Acid
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