Impairment of IgA Expression and Cell Mediated Immunity Observed on Peyer’s Patches of Protein-Depleted Rats at Weaning and Then Fed on 20% Casein

  • M. E. Roux
  • M. Carmen del Lopez
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


The gastrointestinal immune system has many unique structural and functional features, that include the Peyer’s patch and the secretory IgA system (1). Precursors of the IgA plasma cells are first recognizable as bone marrow-derived B cells in the Peyer’s patches (1–3). IgA committed Peyer’s patch cells, that bear surface IgA, leave Peyer’s patches to mesenteric lymph nodes, where they further maturate and acquire the capacity to seed the intestinal lamina propria as IgA plasma cells (2,4).


Casein Diet Delay Type Hypersensitivity Reaction Intestinal Lamina Propria Refed Animal Secretory Immune System 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. E. Roux
    • 1
  • M. Carmen del Lopez
    • 1
  1. 1.Experimental Nutrition and Food Science Department Cellular Immunology Division, Faculty of Pharmacy and BiochemistryUniversity of Buenos AiresBuenos AiresArgentina

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