Barrier Defense Function of the Small Intestine: Effect of Ethanol and Acute Burn Trauma
Nonspecific barriers to the passage of infectious and/or potentially toxic macromolecules exist in the small intestine. They include the “unstirred water layer,” a zone of retarded diffusion which would slow the movement of macromolecules toward the mucosal epithelium; a layer of intestinal mucus which would interfere with macromolecule penetration; and finally, the glycocalyx, anchored in the plasmalemma of the epithelial cell (1).
KeywordsSmall Intestine Horse Radish Peroxidase Intestinal Mucus Unstirred Water Layer Small Intestinal Permeability
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