Passage of Dietary Antigens in Man: Kinetics of Appearance in Serum and Characterization of Free and Antibody-Bound Antigen

  • S. Husby
  • S.-E. Svehag
  • J. C. Jensenius
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


The passage of dietary antigens from the human gastrointestinal tract to the blood was indicated already in the 1920’s, by experiments with passive cutaneous anaphylaxis (1). Quantitation of absorbed dietary antigens in healthy adults was later accomplished by the use of radioimmunological techniques (2). Further, dietary antigens have been reported in circulating immune complexes in atopic patients and in normals (3,4) and in patients with IgA-deficiency (5).


Antibody Level Test Meal Keyhole Limpet Hemocyanin Dietary Antigen Immune Aggregate 
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  1. 1.
    Walzer, M., J. Immunol. 11, 249, 1926.Google Scholar
  2. 2.
    Paganelli, R. and Levinsky, R.J., J. Immunol. Meth. 37, 333, 1980.CrossRefGoogle Scholar
  3. 3.
    Paganelli, R., Levinsky, R.J., Brostoff, I. and Wraith, D.G., Lancet 1, 1270, 1979.PubMedCrossRefGoogle Scholar
  4. 4.
    Paganelli, R., Levinsky, R.J. and Atherton, D.J., Clin. Exp. Immunol. 46, 44, 1981.PubMedGoogle Scholar
  5. 5.
    Cunningham-Rundles, C., Eur. J. Immunol. 11, 504, 1981.PubMedCrossRefGoogle Scholar
  6. 6.
    Husby, S., Jensenius, J.C. and Svehag, S-E., Scand. J. Immunol. 22, 83, 1985.PubMedCrossRefGoogle Scholar
  7. 7.
    Husby, S., Jensenius, J.C. and Svehag, S-E., Scand. J. Immunol. 24, 447, 1986.PubMedCrossRefGoogle Scholar
  8. 8.
    Holmskov-Nielsen, U., Erb, K. and Jensenius, J.C, J. Chromat. 297, 225, 1984.CrossRefGoogle Scholar
  9. 9.
    Husby, S., Oxelius, V-A., Teisner, B., Jensenius, J.C. and Svehag, S-E., Int. Archs. Allergy Appl. Immunol. 77, 416, 1985.CrossRefGoogle Scholar
  10. 10.
    Husby, S., Schultz Larsen, F., Hyltoft Peterson, P. and Svehag, S-E., Allergy, 41, 379, 1986.PubMedCrossRefGoogle Scholar
  11. 11.
    Frank, M.M., Lawley, T.J., Hamburger, M.J. and Brown, E.J., Annals Int. Med. 98, 206, 1983.Google Scholar
  12. 12.
    Socken, D.J., Simms, E.S., Nagy, B.R., Fischer, M.R. and Underdown, B.J., J. Immunol. 127, 316, 1981.PubMedGoogle Scholar
  13. 13.
    Brandtzaeg, P., Scand. J. Immunol. 22, 111, 1985.PubMedCrossRefGoogle Scholar
  14. 14.
    Spiegelberg, H.L., Adv. Immunol. 19, 259, 1974.PubMedCrossRefGoogle Scholar
  15. 15.
    Unkeless, J.C., Fleit, H. and Mellman, J.S., Adv. Immunol. 31, 247, 1981.PubMedCrossRefGoogle Scholar
  16. 16.
    Husby, S., Jensenius, J.C. and Svehag, S-E., J. Immunol. Meth. 82, 321, 1985.CrossRefGoogle Scholar
  17. 17.
    Chase, M.S., Proc. Soc. Exp. Biol. Med. 61, 257, 1946.PubMedGoogle Scholar
  18. 18.
    Swarbrick, E.T., Stokes, CR. and Soothill, J.F., Gut 20, 121, 1979.PubMedCrossRefGoogle Scholar
  19. 19.
    Lim, P.L. and Rowley, D., Int. Archs. Allergy Appl. Immunol. 68, 41, 1982.CrossRefGoogle Scholar
  20. 20.
    Tolo, K., Brandtzaeg, P. and Jonsen, J., Immunology 33, 733, 1977.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • S. Husby
    • 1
  • S.-E. Svehag
    • 1
  • J. C. Jensenius
    • 1
  1. 1.Institute of Medical MicrobiologyOdense UniversityOdense CDenmark

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