The Effects of Moderate Protein Deficiency or High vitamin E on Intestinal Secretory and Serum IgA Levels in Mice
Vitamin E, which is a powerful antioxidant, also has a marked effect on resistance to bacterial infection through enhancing the humoral immune response to antigenic stimulation (1). Tanaka et al. (2), studied the effect of vitamin E on the humoral immune response by testing its influence on antibody production in mice using a hapten-carrier conjugate as an antigen. They found that although vitamin E supplementation does not augment either initial IgM or late IgG responses, it seems to facilitate the shift of antibody production from IgM to IgG. They suggested that vitamin E stimulates the helper activity of T lymphocytes. Tengerdy et al. (3) reported that the humoral immune response of mice against sheep red blood cells or tetanus toxoid antigens was increased by 30–40% when the food was supplemented by vitamin E (60–180 mg/kg). Similar results were reported by Nockels (4). Campbell et al. (5), demonstrated that the addition of vitamin E to the medium can stimulate the response of nonadherent spleen cells to sheep red blood cells in the relative absence of adherent cells. They also showed that vitamin E enhances in vitro immune responses by populations of spleen cells containing both adherent and nonadherent cells.
KeywordsProtein Diet Humoral Immune Response High Vitamin Intestinal Secretion Intestinal Wash
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