The Effects of Moderate Protein Deficiency or High vitamin E on Intestinal Secretory and Serum IgA Levels in Mice

  • R. R. Watson
  • N. Messiha
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Vitamin E, which is a powerful antioxidant, also has a marked effect on resistance to bacterial infection through enhancing the humoral immune response to antigenic stimulation (1). Tanaka et al. (2), studied the effect of vitamin E on the humoral immune response by testing its influence on antibody production in mice using a hapten-carrier conjugate as an antigen. They found that although vitamin E supplementation does not augment either initial IgM or late IgG responses, it seems to facilitate the shift of antibody production from IgM to IgG. They suggested that vitamin E stimulates the helper activity of T lymphocytes. Tengerdy et al. (3) reported that the humoral immune response of mice against sheep red blood cells or tetanus toxoid antigens was increased by 30–40% when the food was supplemented by vitamin E (60–180 mg/kg). Similar results were reported by Nockels (4). Campbell et al. (5), demonstrated that the addition of vitamin E to the medium can stimulate the response of nonadherent spleen cells to sheep red blood cells in the relative absence of adherent cells. They also showed that vitamin E enhances in vitro immune responses by populations of spleen cells containing both adherent and nonadherent cells.


Protein Diet Humoral Immune Response High Vitamin Intestinal Secretion Intestinal Wash 
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  1. 1.
    Tengerdy, R.P., Heinzerling, R.H. and Nockels, C.F., Infect. Immun. 5, 987, 1972.PubMedGoogle Scholar
  2. 2.
    Tanaka, J., Fjuiwara, H. and Torisu, M., Immunology 38, 727, 1979.PubMedGoogle Scholar
  3. 3.
    Tengerdy, R.P., Heinzerling, R.H., Brown, G.L. and Mathias, M.M., Int. Arch. Allergy 44, 221, 1973.PubMedCrossRefGoogle Scholar
  4. 4.
    Nockels, C.F., Fed. Proc. 38, 2134, 1979.PubMedGoogle Scholar
  5. 5.
    Campbell, P.A., Cooper, H.R., Heinzerling, R.H. and Tengerdy, R.P., Proc. Soc. Exp. Biol. Med. 146, 465, 1974.PubMedGoogle Scholar
  6. 6.
    Watson, R.R. and Safranski, D., CRC-Handbook Immunol. Aging. pp. 125–139, 1981.Google Scholar
  7. 7.
    Moriguchi, S., Werner, L. and Watson, R.R., Immunology 56, 169, 1985.PubMedGoogle Scholar
  8. 8.
    Watson, R.R., McMurray, D.N., Martin, P. and Reyes, M.A., Am. J. Clin. Nutr. 42, 281, 1985.PubMedGoogle Scholar
  9. 9.
    Carlomagno, M.A., Alito, A.E., Almiron, D.I. and Geraino, A., Infect. Immun. 38, 195, 1982.PubMedGoogle Scholar
  10. 10.
    Miranda, R., Saravia, N.G., Ackerman, R., Murphy, N., Berman, S. and McMurray, D.N., Am. J. Clin. Nutr. 37, 632, 1983.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • R. R. Watson
    • 1
  • N. Messiha
    • 2
  1. 1.Department of Family and Community MedicineUniversity of ArizonaTucsonUSA
  2. 2.Department of Food and NutritionPurdue UniversityWest LafayetteUSA

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