Effect of Substance P on Human Lymphocyte Proliferation in Vitro: A Comparison between Normal and Birch Pollen Allergic Individuals
The hyperreactivity in allergic patients has been proposed to be a consequence of a wide range of effector mechanisms, including both the autonomous and the immune systems. In 1968, Szentivanyi proposed in his beta-adrenergic blockade theory that bronchial hyperreactivity and related atopic abnormalities might be caused by a decreased beta-adrenergic responsiveness (1). Such abnormality has also been found in the lymphocyte populations, which exhibit different reactivity to beta-adrenergic compounds compared with that of the cells of normal individuals (2). Lymphocytes from atopic patients also seem to have altered reactivity to mediators from inflammatory cells (3).
KeywordsGlutamine Garamycin Rhinitis Mast
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