Mucosal Immunity and Tolerance in Neonatal Rabbits
It has been known for many years that neonatal rabbits are made tolerant by the feeding or injection of bovine serum albumin (BSA) (1–3). On the other hand, older (20+ days) orally immunized rabbit kits respond with anti-BSA production (4), primarily of the IgG subclass (5). Under some conditions, 20 d old kits from orally immunized dams are suppressed in their immune responses to either orally or parenterally administered BSA (4). A study of possible factors in milk that affect the responsiveness of neonates shows that anti-BSA of the IgG isotype is readily transferred into milk by the dam and subsequently is absorbed through the gut into the circulation of nursing kits (6). We now present further studies on the maternal regulation of the immune responses of rabbit kits to BSA and the factors involved.
KeywordsBovine Serum Albumin Bovine Serum Albumin Absorption Parenteral Challenge Neonatal Rabbit Maternal Regulation
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