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Delayed Recovery of Orally Induced Tolerance to Proteins in Irradiated and Spleen-Cell Reconstituted Mice

  • D. G. Hanson
  • T. Morimoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

A single intragastric (i.g.) feeding of 20 mg of ovalbumin (OVA) or human gammaglobulin (HGG) to normal adult BDF1 mice produces specific tolerance to later parenteral immunization with the antigen. Previous work showed that the tolerance induced by feeding could subsequently be abolished by lethal whole-body irradiation. OVA-specific antibody responses were indistinguishable in normal and orally-tolerized mice that were irradiated and then injected with normal spleen cells immediately prior to immunization (1). In the present study, we examined the effects of irradiation and “reconstitution” with normal spleen cells on the induction of tolerance by OVA and HGG feeding.

Keywords

Tolerance Induction Villous Height Parenteral Immunization Reconstituted Mouse Farr Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hanson, D.G., yaz, N.M., Mala, L.C.S. and Lynch, J.M., J. Immunol. 123, 2337, 1979.PubMedGoogle Scholar
  2. 2.
    Chiller, J.M. and Weigle, W.O., J. Immunol. 106, 1647, 1971.PubMedGoogle Scholar
  3. 3.
    Hanson, D.G., J. Immunol. 127, 1518, 1981.PubMedGoogle Scholar
  4. 4.
    Quastler, H. and Hampton, J.C., Radiat. Res. 17, 914, 1962.PubMedCrossRefGoogle Scholar
  5. 5.
    Hanson, D.G., Vaz, N.M., Maia, L.C.S., Hornbrook, M.M., Lynch, J.M. and Roy, C.A., Int. Arch. Allergy Appl. Immunol. 55, 526, 1977.PubMedCrossRefGoogle Scholar
  6. 6.
    Bruce, M.G., Strobel, S., Hanson, D.G. and Ferguson, A., Intestinal antigen processing is eliminated following irradiation and is restored by normal spleen cells. (In preparation for publication)Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • D. G. Hanson
    • 1
  • T. Morimoto
    • 2
  1. 1.Department of Pediatrics, Harvard Medical School and Combined Program in Pediatric Gastroenterology and NutritionMassachusetts General HospitalBostonUSA
  2. 2.Department of MedicineToneyama National HospitalOsakaJapan

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