Pulmonary Cellular Reactions to Schistosoma Mansoni Schistosomula in Normal and Vaccinated Mice

  • J. E. Crabtree
  • R. A. Wilson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Mice vaccinated with radiation-attenuated Schistosoma mansoni cercariae develop significant resistance to challenge infections (1,2). The resistance generated is both species specific (3) and dependent on a functional B and T cell system (4). Elucidation of the effector mechanisms of protective immunity has been complicated by the complex migratory pathway of the parasite, which involves passage through the pulmonary capillaries (5). In vitro studies have shown that newly transformed (skin) schistosomula are susceptible to a variety of immune effector mechanisms involving antibody, complement and leucocytes. Later developmental stages are refractory (reviewed in ref. 6). In vivo, however, there is little morphological evidence of skin attrition of challenge parasites in vaccinated mice (7,8). Moreover, a recent autoradiographic tracking study using 75Selenomethionine-labeled parasites has shown the lungs to be the major site of challenge elimination (9). This suggests that mucosal immune responses might have a significant role in vaccine-induced resistance. To investigate the effector mechanisms involved in immunity, we have undertaken a histopathological and ultrastructural examination of pulmonary cellular responses to schistosomula in normal and vaccinated mice.


Normal Mouse Pulmonary Inflammation Schistosoma Mansoni Mucosal Immune Response United Kingdom Introduction 
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  1. 1.
    Minard, P., Dean, D.A., Jacobson, R.H., Vannier, W.E. and Murrell, K.D., Am. J. Trop. Med. Hyg. 27, 76, 1978.PubMedGoogle Scholar
  2. 2.
    Bickle, Q.D., Taylor, M.C., Doenhoff, M.J. and Nelson, G.S., Parasitology 79, 209, 1979.PubMedCrossRefGoogle Scholar
  3. 3.
    Bickle, Q.D., Andrews, B.J., Doenhoff, M.J., Ford, M.J. and Taylor, M.C., Parasitology 90, 301, 1985.PubMedCrossRefGoogle Scholar
  4. 4.
    Sher, A., Hieny, S., James, S.L. and Asofsky, R., J. Immunol. 128, 1880, 1982.PubMedGoogle Scholar
  5. 5.
    Crabtree, J.E. and Wilson, R.A., Parasitology 92, 343, 1986.PubMedCrossRefGoogle Scholar
  6. 6.
    Smithers, S.R. and Doenhoff, M.J., in Immunology of Parasite Infections (Edited by Cohen, S. and Warren, K), p. 527, Blackwell Scientific Publications, Oxford, 1982.Google Scholar
  7. 7.
    Mastin, A., Bickle, Q.D. and Wilson, R.A., Parasitology 87, 87, 1983.PubMedCrossRefGoogle Scholar
  8. 8.
    von Lichtenberg, F., Correa-Oliveira, R. and Sher, A., Am. J. Trop. Med. Hyg. 34, 96, 1985.Google Scholar
  9. 9.
    Wilson, R.A., Coulson, P. and Dixon, B., Parasitology 92, 101, 1986.PubMedCrossRefGoogle Scholar
  10. 10.
    Crabtree, J.E. and Wilson, R.A., J. Helminth. 60, 75, 1986.PubMedCrossRefGoogle Scholar
  11. 11.
    Sher, A., James, S.L., Simpson, A.J.G., Lazdins, J.K. and Meltzer, M.S., J. Immunol. 128, 1880, 1982.PubMedGoogle Scholar
  12. 12.
    James, S.L. and Sher, A., Parasite Immunol. 5, 567, 1983.PubMedCrossRefGoogle Scholar
  13. 13.
    James, S.L., Natovitz, P.C., Farrar, W.L. and Leonard, E.J., Infect. Immun. 44., 569, 1984.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. E. Crabtree
    • 1
  • R. A. Wilson
    • 2
  1. 1.Department of MedicineSt. James University HospitalLeedsEngland
  2. 2.Department of BiologyUniversity of YorkYorkUK

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