Pulmonary Cellular Reactions to Schistosoma Mansoni Schistosomula in Normal and Vaccinated Mice
Mice vaccinated with radiation-attenuated Schistosoma mansoni cercariae develop significant resistance to challenge infections (1,2). The resistance generated is both species specific (3) and dependent on a functional B and T cell system (4). Elucidation of the effector mechanisms of protective immunity has been complicated by the complex migratory pathway of the parasite, which involves passage through the pulmonary capillaries (5). In vitro studies have shown that newly transformed (skin) schistosomula are susceptible to a variety of immune effector mechanisms involving antibody, complement and leucocytes. Later developmental stages are refractory (reviewed in ref. 6). In vivo, however, there is little morphological evidence of skin attrition of challenge parasites in vaccinated mice (7,8). Moreover, a recent autoradiographic tracking study using 75Selenomethionine-labeled parasites has shown the lungs to be the major site of challenge elimination (9). This suggests that mucosal immune responses might have a significant role in vaccine-induced resistance. To investigate the effector mechanisms involved in immunity, we have undertaken a histopathological and ultrastructural examination of pulmonary cellular responses to schistosomula in normal and vaccinated mice.
KeywordsNormal Mouse Pulmonary Inflammation Schistosoma Mansoni Mucosal Immune Response United Kingdom Introduction
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