Role of LPS Responsiveness in Urinary Tract Infection
The inability of C3H/HeJ mice to respond to endotoxin (5,8,9) affects their susceptibility to infection with gram negative organisms such as Klebsiella, Salmonella typhimurium and Escherichia coli (2–4,7). Linkage of susceptibility to infection and the LPS defective phenotype has been inferred by genetic analysis (4). We have recently shown that C3H/HeJ mice have an increased susceptibility to E. coli kidney infection (1). Susceptibility was correlated with the lps d gene, although strict linkage has not yet been proven.
KeywordsPost Infection Giemsa Stain Bacterial Persistence Kidney Infection Cytocentrifuge Preparation
Unable to display preview. Download preview PDF.
- 3.Hagberg, L., Briles, D.E. and Svanborg-Eden, C., J. Immunol. 134, 4119, 1985.Google Scholar