Role of LPS Responsiveness in Urinary Tract Infection

  • R. Shahin
  • L. Hagberg
  • I. Engberg
  • C. Svanborg-Eden
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


The inability of C3H/HeJ mice to respond to endotoxin (5,8,9) affects their susceptibility to infection with gram negative organisms such as Klebsiella, Salmonella typhimurium and Escherichia coli (2–4,7). Linkage of susceptibility to infection and the LPS defective phenotype has been inferred by genetic analysis (4). We have recently shown that C3H/HeJ mice have an increased susceptibility to E. coli kidney infection (1). Susceptibility was correlated with the lps d gene, although strict linkage has not yet been proven.


Post Infection Giemsa Stain Bacterial Persistence Kidney Infection Cytocentrifuge Preparation 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • R. Shahin
    • 1
  • L. Hagberg
    • 1
  • I. Engberg
    • 1
  • C. Svanborg-Eden
    • 1
  1. 1.Department of Clinical ImmunologyUniversity of GoteborgGoteborgSweden

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