Novel Regulatory Mechanisms of IgA Synthesis: Respective Roles of Neuropeptides and Cells of the Anti-Suppressor Circuit
IgA has been recognized as the predominant class of antibody in mucosal secretions even though it constitutes a relatively small percentage of serum immunoglobulin. There are several mechanisms that contribute to IgA making up such a large proportion of the antibody in intestinal secretions (reviewed in ref. 1) including: a high frequency of IgA B cell precursors in Peyer’s patches (2); T cells which facilitate an isotype switch from IgM to IgA (so called switch T cell) (3); IgA-specific helper T cells (4); a propensity of these cells to traffic selectively to mucosal surfaces (1); and the existence of a specific mechanism to facilitate the transport of IgA across the epithelium into secretions (5). In this paper, we report our data concerning two other mechanisms that may be capable of enhancing IgA production, namely neuropeptides and the antisuppressor regulatory circuit.
KeywordsEffector Cell Immunoglobulin Synthesis Cell Enrich Population Nylon Wool Column Complement Mediate Cytolysis
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