Novel Regulatory Mechanisms of IgA Synthesis: Respective Roles of Neuropeptides and Cells of the Anti-Suppressor Circuit

  • P. B. Ernst
  • A. M. Stanisz
  • R. Scicchitano
  • F. Paraskevas
  • D. Payan
  • J. Bienenstock
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


IgA has been recognized as the predominant class of antibody in mucosal secretions even though it constitutes a relatively small percentage of serum immunoglobulin. There are several mechanisms that contribute to IgA making up such a large proportion of the antibody in intestinal secretions (reviewed in ref. 1) including: a high frequency of IgA B cell precursors in Peyer’s patches (2); T cells which facilitate an isotype switch from IgM to IgA (so called switch T cell) (3); IgA-specific helper T cells (4); a propensity of these cells to traffic selectively to mucosal surfaces (1); and the existence of a specific mechanism to facilitate the transport of IgA across the epithelium into secretions (5). In this paper, we report our data concerning two other mechanisms that may be capable of enhancing IgA production, namely neuropeptides and the antisuppressor regulatory circuit.


Effector Cell Immunoglobulin Synthesis Cell Enrich Population Nylon Wool Column Complement Mediate Cytolysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ernst P.B., Scicchitano, R., Underdown, B.J. and Bienenstock, J., in Immunology of the Gastrointestinal Tract and Liver, (Edited by Jones, R., Heyworth, M. and Owen, R.), Raven Press, New York (in press).Google Scholar
  2. 2.
    Craig, S.W. and Cebra, J.J., J. Exp. Med. 134, 188, 1971.PubMedCrossRefGoogle Scholar
  3. 3.
    Kawanishi, H., Saltzman, L.E. and Strober, W., J. Exp. Med. 157, 433, 1983.PubMedCrossRefGoogle Scholar
  4. 4.
    Kiyono, H., Cooper, M.D., Kearney, J.F., Mosteller, L.M., Michalek, S.M., Koopman, W.J. and McGhee, J.R., J. Exp. Med. 159, 798, 1984.PubMedCrossRefGoogle Scholar
  5. 5.
    Underdown, B.J. and Schiff, J.M., Ann. Rev. of Immunol. 4, 389, 1986.CrossRefGoogle Scholar
  6. 6.
    Stanisz, A.M., Befus, A.D. and Bienenstock, J., J. Immunol. 136, 152, 1986.PubMedGoogle Scholar
  7. 7.
    Payan, D.G., Brewster, D.R., Missirian-Bastian, A. and Goetzl, E.J., J. Clin. Invest. 74, 1532, 1984.PubMedCrossRefGoogle Scholar
  8. 8.
    Payan, D.G., Brewster, D.R. and Goetzl, E.J., J. Immunol. 133, 3260, 1984.PubMedGoogle Scholar
  9. 9.
    Paraskevas, F., Lee, S.-T. and Al-Maghazachi, A., Lymphokines 9, 201, 1984.Google Scholar
  10. 10.
    Paraskevas, F., ee, S.-T. and Al-Maghazachi, A., Surv. Immunol. Res. 3, 15, 1984.Google Scholar
  11. 11.
    Orr, K.R. and Paraskevas, F., J. Immunol. 110, 456, 1973.PubMedGoogle Scholar
  12. 12.
    Paraskevas, F., Lee, S.-T., Maeba, J. and David, C.S., Cell. Immunol. 92, 53, 1985.PubMedCrossRefGoogle Scholar
  13. 13.
    Lee, S.-T., Paraskevas, F. and Maeba, J., Cell. Immunol. 92, 64, 1985.PubMedCrossRefGoogle Scholar
  14. 14.
    Paraskevas, F., Lee, S.-T. and Maeba, J., Cell. Immunol. 92, 74, 1985.PubMedCrossRefGoogle Scholar
  15. 15.
    Bhathena, S.J., Lovie, J., Schecheter, G.P., Redman, R.S., Wahl, L. and Recant, L., Diabetes 30, 127, 1981.PubMedCrossRefGoogle Scholar
  16. 16.
    Ottaway, C.A. and Greenberg, G.R., J. Immunol. 132, 417, 1984.PubMedGoogle Scholar
  17. 17.
    Besedovsky, H.O., Rey, A.E. and Sorkin, E., Immunol. Today 4, 342, 1983.CrossRefGoogle Scholar
  18. 18.
    Rayan, D.G., Hess, C.A. and Goetzl, E.J., Cell. Immunol. 84, 422, 1984.CrossRefGoogle Scholar
  19. 19.
    Ottaway, C.A., Bernaerts, C., Chan, B. and Greenberg, G.R., Can. J. Physiol. Pharmacol. 61, 664, 1983.PubMedCrossRefGoogle Scholar
  20. 20.
    Danek, A., O’Dorisio, M.S., O’Dorisio, T.M. and George, J.M., J. Immunol. 131, 1173, 1983.PubMedGoogle Scholar
  21. 21.
    Johnson, H.M., Smith, E.M., Torres, B.A. and Blalock, J.E., Proc. Natl. Acad. Sci. USA 79, 4171, 1982.PubMedCrossRefGoogle Scholar
  22. 22.
    Gilman, S.C., Schwartz, J.M., Milner, R.J., Bloom, F.E. and Feldman, J.D., Proc. Natl. Acad. Sci. USA 79, 4226, 1982.PubMedCrossRefGoogle Scholar
  23. 23.
    Hartung, H.P., Wolters, K. and Toyka, K.V., J. Immunol. 136, 3856, 1986.PubMedGoogle Scholar
  24. 24.
    Ottaway, C.A., J. Exp. Med. 160, 1054, 1986.CrossRefGoogle Scholar
  25. 25.
    Payan, D.G., Brewster, D.R. and Goetzl, E.J., J. Immunol. 131, 1613, 1983.PubMedGoogle Scholar
  26. 26.
    Payan, D.G., Brewster, D.R., Missirian-Bistra, A. and Goetzl, E.J., J. Clin. Invest 74, 1532, 1984.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • P. B. Ernst
    • 1
  • A. M. Stanisz
    • 1
  • R. Scicchitano
    • 1
  • F. Paraskevas
    • 2
  • D. Payan
    • 3
  • J. Bienenstock
    • 1
  1. 1.Department of Pathology and Intestinal Disease Research UnitMcMaster UniversityHamiltonCanada
  2. 2.Department of ImmunologyUniversity of ManitobaWinnepegCanada
  3. 3.Department of MedicineUniversity of California at San FranciscoSan FranciscoUSA

Personalised recommendations