Gut Injury in Mouse Graft-Versus-Host Reaction (GVHR)

  • D. Guy-Grand
  • P. Vassalli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


The gut is one of the main targets of acute GVHR in man and the pathogenesis of the injury is poorly understood. Using various experimental models in mice we tried (1) to shed some light on the occurrence, nature and mechanism of lesions. Our observations led us to the conclusion that the basic situation responsible for intestinal tissue damage is the stimulation of the foreign “donor” T lymphocytes. T lymphocytes activated to proliferate under alloantigenic influence in Peyer’s patches, reach the gut wall through the thoracic duct (2) and are further stimulated by contact with antigen. Release of T cell factors are probably mainly responsible for the acceleration of the epithelial renewal which is the most sensitive index of the epithelial damage.


Lymphoid Organ Thoracic Duct L3T4 Cell Newborn Mouse Crypt Epithelial Cell 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • D. Guy-Grand
    • 1
    • 2
  • P. Vassalli
    • 1
    • 2
  1. 1.Institut National de la Santé et de la Recherche MédicaleU 132 Hopital Necker-Enfants MaladesParisFrance
  2. 2.Department de PathologieUniversite de GeneveGeneve 5Switzerland

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