Mucosal Mast Cells and the Intestinal Epithelium

  • M. H. Perdue
  • D. G. Gall
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Mast cell numbers in the mucosa of the small intestine are increased in a number of clinical and experimental conditions such as inflammatory bowel disease, intestinal infections (particularly parasitic infestations), celiac disease, graft-versus-host disease, and possibly in food allergy (1). These conditions may involve some degree of villus atrophy. Abnormalities of intestinal function which usually include diarrhea are prevalent. Are the functional changes related to the action of mast cell mediators? Our studies investigating the effects of mast cell mediators on the epithelium in anaphyactic rats suggest that they are.


Mast Cell Celiac Disease Food Allergy Sodium Cromoglycate Sucrase Activity 
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  1. 1.
    Bienenstock, J., Befus, A.D. and Denburg, J., in Mast Cell Heterogeneity (Edited by Befus, A.D., Bienenstock, J. and Denburg, J.), pp. 391, Raven Press, New York, 1986.Google Scholar
  2. 2.
    Perdue, M.H. and Gall, D.G., Gastroenterology 86, 391, 1984.PubMedGoogle Scholar
  3. 3.
    Perdue, M.H. and Gall, D.G., J. Allergy Clin. Immunol. 76, 498, 1985.PubMedCrossRefGoogle Scholar
  4. 4.
    Pearce, F.L., Befus, A.D., Gauldie, J. and Bienenstock, J., J. Immunol. 128, 2481, 1982.PubMedGoogle Scholar
  5. 5.
    Perdue, M.H., Forstner, J.F., Roomi, N.W. and Gall, D.G., Am. J. Physiol. 247, G632, 1984.PubMedGoogle Scholar
  6. 6.
    Perdue, M.H. and Gall, D.G., Am. J. Physiol. 250, G427, 1986.PubMedGoogle Scholar
  7. 7.
    Marom, Z. and Casale, T.B., Ann. Allergy 50, 367, 1983.PubMedGoogle Scholar
  8. 8.
    Dunn, I.J., Buvet, A., Miller, H.J., Huntley, J.R., Gibson, S. and Gall, D.G., Gastroenterology 90, 1401, 1986.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. H. Perdue
    • 1
    • 2
  • D. G. Gall
    • 1
    • 2
  1. 1.Intestinal Disease Research UnitsMcMaster UniversityHamiltonCanada
  2. 2.University of CalgaryCalgaryCanada

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