Mast Cell Pleomorphism: Properties of Intestinal Mast Cells
Consistent with their nearly ubiquitous distribution throughout the body, mast cells interact with a variety of cell types and react to numerous environmental stimuli. They can be activated by macrophage (1) and T cell factors (2), by complement fragments, as well as by IgE-allergen interactions. However, mast cells are involved in more than immediate hypersensitivity reactions because under appropriate conditions their mediators play a role in cell and organismal toxicity, immunoregulation, promotion of neovascularization and fibroblast proliferation (3). Moreover, mast cells and the nervous system appear to communicate with one another, an association that implies important physiological functions. For example, intimate contact between mast cells and nerves is common (i.e., 4,5), vagus nerve stimulation enhances antigen-induced histamine release (6); and neuropeptides and endorphins degranulate mast cells (7,8). Whether mast cells activate nerves and are, therefore, engaged in bidirectional interchanges is unclear.
KeywordsMast Cell Vagus Nerve Stimulation Human Mast Cell Peritoneal Mast Cell Mucosal Mast Cell
Unable to display preview. Download preview PDF.
- 5.Stead, R.H., Tomioka, M., Quinonez, G., Simon, G., Feiten, D.L. and Bienenstock, J., Proc. Natl. Acad. Sci., 1987 (in press).Google Scholar
- 10.Enerback, L., in Mast Cell Differentiation and Heterogeneity, (Edited by Befus, A.D., Bienenstock, J. and Denburg, J.A.), p. 1, Raven Press, New York, 1986.Google Scholar
- 15.Woodbury, R.G., Everitt, M.T. and Neurath, H., Method. Enzymol. 80, 45, 1981.Google Scholar
- 22.Befus, D., Dyck, N., Goodacre, R. and Bienenstock, J., J. Immunol., 1987 (in press).Google Scholar
- 23.Schwartz, L.B. and Austen, K.F., Prog. Allergy 4, 271, 1984.Google Scholar
- 25.Swieter, M., Lee, T.D.G., Stead, R.H. and Befus, D., Fed. Proc. 45, 388, 1986.Google Scholar