Mast Cell Pleomorphism: Properties of Intestinal Mast Cells

  • M. Swieter
  • T. D. G. Lee
  • R. H. Stead
  • H. Fujimaki
  • D. Befus
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Consistent with their nearly ubiquitous distribution throughout the body, mast cells interact with a variety of cell types and react to numerous environmental stimuli. They can be activated by macrophage (1) and T cell factors (2), by complement fragments, as well as by IgE-allergen interactions. However, mast cells are involved in more than immediate hypersensitivity reactions because under appropriate conditions their mediators play a role in cell and organismal toxicity, immunoregulation, promotion of neovascularization and fibroblast proliferation (3). Moreover, mast cells and the nervous system appear to communicate with one another, an association that implies important physiological functions. For example, intimate contact between mast cells and nerves is common (i.e., 4,5), vagus nerve stimulation enhances antigen-induced histamine release (6); and neuropeptides and endorphins degranulate mast cells (7,8). Whether mast cells activate nerves and are, therefore, engaged in bidirectional interchanges is unclear.


Mast Cell Vagus Nerve Stimulation Human Mast Cell Peritoneal Mast Cell Mucosal Mast Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. Swieter
    • 1
    • 2
  • T. D. G. Lee
    • 1
    • 2
  • R. H. Stead
    • 1
    • 2
  • H. Fujimaki
    • 1
    • 2
  • D. Befus
    • 1
    • 2
  1. 1.Gastrointestinal Research UnitUniversity of CalgaryCalgaryCanada
  2. 2.The Department of PathologyMcMaster UniversityHamiltonCanada

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