In Vitro Effects of IgA on Human Polymorphonuclear Leukocytes
Receptors for immunoglobulin A (IgA) have been demonstrated on human polymorphonuclear leukocytes (PMN), monocytes and macrophages (1–3). However, little is known about the effector function of this Ig on human phagocytes. Recently, IgA was reported to have inhibitory effects on several effector functions of human PMN such as Chemotaxis towards various chemoattractants (4), bactericidal activity (5), phagocytosis (5) and formyl-methionyl-leucyl-phenylalanine (FMLP)-stimulated chemiluminescence (6). However, these effects contrast with the increase of PMN cytotoxicity by IgA and with the absence of influence of IgA on Zymosan-induced chemiluminescence or on capping of PMN with fluorescent concanavalin A (7).
KeywordsHuman Serum Albumin Human Polymorphonuclear Leukocyte Ficoll Hypaque Density Gradient Centrifugation Chemotaxis Chamber High Power Microscopic Field
Unable to display preview. Download preview PDF.