RFc Alpha-Bearing Cells and IgA-Mediated Phagocytosis in the Mouse Oral Mucosa
IgA, the predominant immunoglobulin in the saliva, is the principal mediator of specific immunity in the oral cavity. Because IgA does not fix complement it is generally assumed that it is inefficient in acting directly as a bactericidal antibody (1). It is not excluded, however, that IgA can mediate bactericidal mechanisms by interaction with effector cells. Recently, receptors for the Fc portion of IgA have been demonstrated on different cell types (2–6). Moreover, some effector cells (lymphocytes, PMN, peripheral monocytes) were shown to kill bacteria via IgA-dependent mechanisms (7–10).
KeywordsAcridine Orange Phagocytic Index Bacterial Ingestion Mouse Oral Bactericidal Antibody
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