RFc Alpha-Bearing Cells and IgA-Mediated Phagocytosis in the Mouse Oral Mucosa

  • J. Barbeau
  • J. Bourget
  • N. Deslauriers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


IgA, the predominant immunoglobulin in the saliva, is the principal mediator of specific immunity in the oral cavity. Because IgA does not fix complement it is generally assumed that it is inefficient in acting directly as a bactericidal antibody (1). It is not excluded, however, that IgA can mediate bactericidal mechanisms by interaction with effector cells. Recently, receptors for the Fc portion of IgA have been demonstrated on different cell types (2–6). Moreover, some effector cells (lymphocytes, PMN, peripheral monocytes) were shown to kill bacteria via IgA-dependent mechanisms (7–10).


Acridine Orange Phagocytic Index Bacterial Ingestion Mouse Oral Bactericidal Antibody 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. Barbeau
    • 1
  • J. Bourget
    • 1
  • N. Deslauriers
    • 1
  1. 1.Department de biochimie, faculte des sciences et genie and groupe de recherche en ecologie buccale (GREB) Ecole de medecine dentaireUniversite LavalQuebecCanada

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