Inhibition of Natural Killer (NK) Activity by Human Colostral and Serum IgA
Natural killer (NK) cells are defined as effector cells with spontaneous cytotoxicity against tumor, virus-infected and undifferentiated normal cells. NK activity is closely associated with a subpopulation of lymphocytes, large granular lymphocytes (LGL), that contain azurophilic cytoplasmic granules. The NK cells show a characteristic organ distribution: they are numerous in peripheral blood and spleen, but relatively low numbers are found in lymph nodes, peritoneal cavity and bone marrow (1,2). Previous investigations have demonstrated that NK activity is influenced by various factors such as interferon, interleukin-2, hormones, suppressor cells, environmental factors and age. Recently, mucosal LGL have been isolated from the small intestines of humans, mice and rats (3–6). In the mouse and rat, mucosal LGL showed moderate levels of NK activity, while human mucosal LGL demonstrated low NK activity.
KeywordsNatural Killer Natural Killer Cell Natural Killer Activity Large Granular Lymphocyte K562 Target Cell
Unable to display preview. Download preview PDF.
- 1.Ortaldo, J.R., Herberman, R.B., in Annual Review of Immunology, (Edited by William, P.E.), Vol. 2, pp. 359–394, Annual Reviews, Palo Alto, CA, 1984.Google Scholar
- 8.Komiyama, K., Hirsch, H.Z., Mestecky, J. and Moro, I., Fed. Proc. 45, 953 (Abstr. 4648), 1986.Google Scholar
- 9.Mestecky, J. and Russell, M.W., Mongr. Allergy 19, 277, 1986.Google Scholar