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Potentiation of Rat Colon Intraepithelial Lymphocyte (IEL) Natural Killer (NK) Activity with Indomethacin

  • D. S. Ross
  • T. R. Roy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

Natural killer (NK) cells are thought to play a central role in host immunosurveillance against the development and dissemination of cancer (1–3). The role of gut associated lymphoid tissue (GALT) in anti-tumor host defense is not known. It is logical to assume that a malignancy developing within a specific organ would first encounter local immune elements. Rats treated with the colon carcinogens 1,2-Dimethylhydrazine have been widely used as a model of human colon carcinoma (4). In addition, this model is suitable for studying the immune response to large bowel cancer (5). The purpose of this study is to determine whether there is NK activity in rat colon intraepithelial lymphocytes (IEL) and whether treatment with the prostaglandin synthetase inhibitor, indomethacin, will enhance NK function.

Keywords

Natural Killer Natural Killer Activity Splenic Lymphocyte 51Cr Release Large Bowel Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Herberman, R.B. and Ortaldo, J.R., Science 214, 24, 1981.PubMedCrossRefGoogle Scholar
  2. 2.
    Flannery, G.R. and Brooks, C.G., Int. J. Cancer 28, 747, 1981.PubMedCrossRefGoogle Scholar
  3. 3.
    Wiltrout, R.H., Herberman, R.B., Zhang, S.R., Chirigos, M.A., Ortaldo, J.R., Green, K.M. and Talmadge, J.E., J. Immunol. 134, 4267, 1985.PubMedGoogle Scholar
  4. 4.
    Lamont, J.T. and O’Gorman, T.A., Gastroenterology 75, 1157, 1978.PubMedGoogle Scholar
  5. 5.
    Sjogen, H.O. and Steele, G., Jr., Cancer 36, 2469, 1975.CrossRefGoogle Scholar
  6. 6.
    Bland, P.W., Britton, D.C., Richens, E.R. and Pledger, J.V., Gut 22, 744, 1981.PubMedCrossRefGoogle Scholar
  7. 7.
    Vose, B.M., Gallagher, P., Moore, M. and Schofield, P.F., Br. J. Cancer 44, 846, 1981.PubMedCrossRefGoogle Scholar
  8. 8.
    Pollard, M. and Luckert, P.H., Cancer Treat Rep. 64, 1323, 1980.PubMedGoogle Scholar
  9. 9.
    Metzger, U., Meier, J., Uhlschmid, G. and Weihe, H., Dis. Colon Rectum 27, 366, 1984.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • D. S. Ross
    • 1
  • T. R. Roy
    • 1
  1. 1.Section of Surgical Oncology, Department of SurgerySouthern Illinois University School of MedicineSpringfieldUSA

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