Potentiation of Rat Colon Intraepithelial Lymphocyte (IEL) Natural Killer (NK) Activity with Indomethacin
Natural killer (NK) cells are thought to play a central role in host immunosurveillance against the development and dissemination of cancer (1–3). The role of gut associated lymphoid tissue (GALT) in anti-tumor host defense is not known. It is logical to assume that a malignancy developing within a specific organ would first encounter local immune elements. Rats treated with the colon carcinogens 1,2-Dimethylhydrazine have been widely used as a model of human colon carcinoma (4). In addition, this model is suitable for studying the immune response to large bowel cancer (5). The purpose of this study is to determine whether there is NK activity in rat colon intraepithelial lymphocytes (IEL) and whether treatment with the prostaglandin synthetase inhibitor, indomethacin, will enhance NK function.
KeywordsNatural Killer Natural Killer Activity Splenic Lymphocyte 51Cr Release Large Bowel Cancer
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