Antibacterial Activity Against Streptococcus Pneumoniae by Mouse Lung Lymphocytes
Despite the presence of a relevant number of lymphoid cells in the lung, organized in follicles and lymphoid aggregates or free in the bronchial mucosa, submucosa, and in the alveolar fluid, the main function of these cells is still largely unknown (1,2). It has been suggested that they might belong to an immunological system common to other mucosae (MALT: mucosa associated lymphoid tissue) and that their main function is the production of immunoglobulins, mostly of the IgA class, which will be transported in secretions (3,4). Recently, however, it has been shown that lymphocytes from the gastrointestinal mucosa may be armed by specific IgA to express antibacterial activity against enteropathogenic organisms (5–7). Since lung lymphocytes (LL) were found to recognize bacterial antigens in vitro (8), and at the same time, to have cytotoxic activity against tumors (9), as also observed with lymphoid cells from other mucosal sites (10), it was of interest to investigate whether a population of LL could also exert antibacterial activity against a respiratory pathogen by means of a mechanism similar to those of other mucosal lymphocytes.
KeywordsAntibacterial Activity Mucosa Associate Lymphoid Tissue Carbonyl Iron Bronchial Mucosa Peritoneal Exudate Cell
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