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Antibacterial Activity Against Streptococcus Pneumoniae by Mouse Lung Lymphocytes

  • P. Sestini
  • L. Nencioni
  • L. Villa
  • D. Boraschi
  • A. Tagliabue
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

Despite the presence of a relevant number of lymphoid cells in the lung, organized in follicles and lymphoid aggregates or free in the bronchial mucosa, submucosa, and in the alveolar fluid, the main function of these cells is still largely unknown (1,2). It has been suggested that they might belong to an immunological system common to other mucosae (MALT: mucosa associated lymphoid tissue) and that their main function is the production of immunoglobulins, mostly of the IgA class, which will be transported in secretions (3,4). Recently, however, it has been shown that lymphocytes from the gastrointestinal mucosa may be armed by specific IgA to express antibacterial activity against enteropathogenic organisms (5–7). Since lung lymphocytes (LL) were found to recognize bacterial antigens in vitro (8), and at the same time, to have cytotoxic activity against tumors (9), as also observed with lymphoid cells from other mucosal sites (10), it was of interest to investigate whether a population of LL could also exert antibacterial activity against a respiratory pathogen by means of a mechanism similar to those of other mucosal lymphocytes.

Keywords

Antibacterial Activity Mucosa Associate Lymphoid Tissue Carbonyl Iron Bronchial Mucosa Peritoneal Exudate Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    McDermott, M.R., Befus, A.D. and Bienenstock, J., Int. Rev. Exp. Pathol. 23, 47, 1982.PubMedGoogle Scholar
  2. 2.
    Clancy, R. and Bienenstock, J., J. Immunol. 112, 1997, 1974.Google Scholar
  3. 3.
    Weisz-Carrington, P., Roux, M.E., McWilliams, M., Phillips-Quagliata, J.M. and Lamm, M.E., J. Immunol. 123, 1705, 1979.PubMedGoogle Scholar
  4. 4.
    McDermott, M.R. and Bienenstock, J., J. Immunol. 124, 2536, 1980.PubMedGoogle Scholar
  5. 5.
    Tagliabue, A., Nencioni, L., Villa, L., Keren, D.F., Howell, G.H. and Boraschi, D., Nature 36, 184, 1983.CrossRefGoogle Scholar
  6. 6.
    Nencioni, L., Villa, L., Boraschi, D., Berti, B. and Tagliabue, A., J. Immunol. 130, 903, 1983.PubMedGoogle Scholar
  7. 7.
    Tagliabue, A., Boraschi, D., Villa, L., Keren, D.F., Lowell, G.H., Rappuoli, R. and Nencioni, L., J. Immunol. 133, 988, 1984.PubMedGoogle Scholar
  8. 8.
    Clancy, R.L., Pucci, A., Jelihovsky, T. and Bye, P., Am Rev. Resp. Dis. 117, 513, 1978.PubMedGoogle Scholar
  9. 9.
    Stein-Streilein, J., Bennett, M., Mann, D. and Kumar, V., J. Immunol. 131, 2699, 1983.PubMedGoogle Scholar
  10. 10.
    Tagliabue, A., Befus, A.D., Clark, D.A. and Bienenstock, J., J. Exp. Med. 155, 1785, 1982.PubMedCrossRefGoogle Scholar
  11. 11.
    Sestini, P., Bozelka, B.E., DeShazo, R.D. and Salvaggio, J.E., Cell. Immunol. 73, 264, 1982.PubMedCrossRefGoogle Scholar
  12. 12.
    Leon, M.A. and Young, N.M., Biochemistry 10, 1424, 1971.PubMedCrossRefGoogle Scholar
  13. 13.
    Dialynas, D.P., Quan, Z.S., Wall, K., Perres, H., Quintans, J., Loken, M., Pierraes, M. and Fitch, F., J. Immunol. 131, 2445, 1983.PubMedGoogle Scholar
  14. 14.
    Lowell, G.H., Smith, L.F., Griffis, J.McL. and Brandt, B.L., J. Exp. Med. 152, 452, 1980.PubMedCrossRefGoogle Scholar
  15. 15.
    Richards, C.D. and Gauldie, J., Am. Rev. Resp. Dis. 32, 82, 1985.Google Scholar
  16. 16.
    Waldman, R.H. and Ganguly, R., J. Infect. Dis. 130, 419, 1974.PubMedCrossRefGoogle Scholar
  17. 17.
    Chipps, B.E., Talamo, R.C. and Winkelstein, J.A., Chest 73, 519 1978.PubMedCrossRefGoogle Scholar
  18. 18.
    Tagliabue, A., Villa, L., Boraschi, D., Peri, G., De Gori, V., Nencioni, L., J. Immunol. 135, 4178, 1985.PubMedGoogle Scholar
  19. 19.
    Abo, T., Sugawara, S., Amenomori, A., et al., J. Immunol. 136, 3189, 1986.PubMedGoogle Scholar
  20. 20.
    Endoh, M., Sakai, H., Nomoto, Y., Tomino, Y. and Kaneshigi, H., J. Immunol. 127, 2613, 1981.Google Scholar
  21. 21.
    Yodoi, J., Adachi, M. and Masuda, T., J. Immunol. 128, 888, 1982.PubMedGoogle Scholar
  22. 22.
    Clancy, R., Cripps, A., Murree-Allen, K., Yeung, S. and Engel, M., Lancet 2, 1395, 1985.PubMedCrossRefGoogle Scholar
  23. 23.
    Tagliabue, A., Nencioni, L., Caffarena, A., Villa, L., Boraschi, D., Cazzola, G. and Cavalieri, S., Clin. Exp. Immunol. 62, 2422, 1985.Google Scholar
  24. 24.
    Briles, D.E., Nahm, M., Schroer, K., Davie, J., Baker, P., Kearney, J. and Barletta, P., J. Exp. Med. 152, 694, 1981.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • P. Sestini
    • 1
  • L. Nencioni
    • 1
  • L. Villa
    • 1
  • D. Boraschi
    • 1
  • A. Tagliabue
    • 1
  1. 1.The Institute of Respiratory DiseasesUniversity of Siena and the Sclavo Research CenterSienaItaly

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