Antibacterial Activity of Lymphocytes Armed with IgA
It is thought that IgA play a major role against bacterial and viral infections, particularly at the mucosal level. However, the mechanisms through which IgA express their activity are still a matter of debate. After the discovery of Fc receptors for IgA (Fcα) in different cellular subpopulations from experimental animals and humans, it was suggested that IgA might also drive mechansims of antibody-dependent cellular cytotoxicity (ADCC). To verify this hypothesis, we investigated whether murine lymphocytes from peripheral and gut associated lymphoid tissues (GALT) were capable of expressing IgA-ADCC against gram-negative bacterial targets. It was, in fact, observed that this activity can be expressed by cells from normal mice (1–5). Similar experiments were, therefore, performed employing human lymphocytes, and the results obtained demonstrated that IgA-ADCC also exists in humans (6–7). A summary of the results obtained so far is presented here, together with our most recent unpublished findings on this subject.
KeywordsAntibacterial Activity Cord Blood Normal Donor Oral Vaccine Mucosal Level
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- 8.Tagliabue, A., Villa, L., Sestini, P., Boraschi, D., De Magistris, M.T. and Nencioni, L., in Mucosal Immunity and Infection of Mucosal Surface, (Edited by Strober, W., McGhee, J. and Lamm, M.), in press.Google Scholar