T Cell-Driven Appearance of Mononuclear Cells, Mast Cells and Goblet Cells in the Respiratory Tract

  • S. Ahlstedt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Inflammatory reactions in the mucosal membranes are often mediated by antibodies of IgE and IgG isotypes. These antibodies work in concert with cells such as granulocytes, mononuclear cells, mast cells and goblet cells (1). The immunological regulation of the antibody formation by T cells and their products has been extensively studied and subsequently established (2). Whether similar regulation of the non-immunological cellular counterparts may occur is still an open question. During parasite infection experimental studies have provided evidence of a T cell triggering of the development of mast cells and goblet cells (3). We have been studying the appearance of cells in the airways of immunized rats and mice after inhalation of antigen.


Mast Cell Goblet Cell Mucous Cell Mast Cell Number Local Challenge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Befus, D. and Bienenstock, J., Prog. Allergy 31, 76, 1982.PubMedGoogle Scholar
  2. 2.
    Ishizaka, K., Yodoi, J., Suemura, M. and Hirashima, M., Immunology Today 4, 192, 1983.CrossRefGoogle Scholar
  3. 3.
    Miller, H.R.P., Nawa, Y. and Parish, C.R., Int. Archs. Allergy appl. Immun. 59, 281, 1979.CrossRefGoogle Scholar
  4. 4.
    Ahlstedt, S., Björkstèn, B., Nygren, H. and Smedegård, G., Immunology 48, 247, 1983.PubMedGoogle Scholar
  5. 5.
    Ahlstedt, S., Smedegård, G., Nygren, H. and Björkstèn, B., Int. Archs. Allergy appl. Immun. 72, 71, 1983.CrossRefGoogle Scholar
  6. 6.
    Enander, I., Ahlstedt, S., Nygren, H. and Bjårksten, B., Int. Archs. Allergy appl. Immun. 72, 59, 1983.CrossRefGoogle Scholar
  7. 7.
    Turk, J.L., Delayed Hypersensitivity, p. 1, North Holland, Amsterdam, 1975.Google Scholar
  8. 8.
    Haig, D.M., McKee, T.A., Jarrett, E.E.E., Woodburry, R. and Miller, H.R.P., Nature (London), 300 188, 1982.CrossRefGoogle Scholar
  9. 9.
    Enander, I., Ulfgren, A., Nygren, H., Holmdahl, R., Klareskog, L. and Ahlstedt, S., Regulation of delayed hypersensitivity reaction in the lung reflected by mononuclear cells, mast cells and mucous cells appearing after T helper cell depletion and adoptive transfer, 1987 (submitted).Google Scholar
  10. 10.
    Enander, I., Nygren, H. and Ahlstedt, S., Immunological suppression of delayed hypersensitivity responses in lungs as reflected by numbers of mononuclear cells, mast cells and mucous cells, 1987 (submitted).Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • S. Ahlstedt
    • 1
  1. 1.Pharmacia Diagnostics AB, Uppsala, and the Department of Clinical ImmunologyUniversity of GöthenburgGöthenburgSweden

Personalised recommendations