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Rabbit Ileal Lamina Propria (LP) Lymphocytes Give Poor Blastogenic Responses to KLH Immunization and Concanavalin a Mitogenesis

  • T. G. Brewer
  • R. H. Reid
  • C. A. Hooper
  • W. T. McCarthy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

A clear understanding of oral immunization responses in animal models of infectious diarrhea is critical for development of effective vaccines against bacterial diarrhea. Work in this laboratory has demonstrated the feasibility of primary in vitro immunization of rabbit Peyer’s patch (PP) antibody by RDEC-1 E. coli pilus protein (1) with’detection of an antigen-specific antibody response (2). Our objective was to develop an in vitro microculture system to demonstrate a primary (T cell) proliferative response to Concanavalin A (Con A) mitogen stimulation and KLH immunization by lamina propria (LP) and Peyer’s patch (PP) cells.

Keywords

Lamina Propria Proliferative Response Keyhole Limpet Hemocyanin Lamina Propria Lymphocyte Lamina Propria Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • T. G. Brewer
    • 1
  • R. H. Reid
    • 1
  • C. A. Hooper
    • 1
  • W. T. McCarthy
    • 1
  1. 1.Department of GastroenterologyWalter Reed Army Institute of ResearchUSA

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