T Cell and Mononuclear Phagocyte Populations of the Human Small and Large Intestine
Considering the diverse roles subsumed by the intestinal mucosal immune system, namely defense against potential luminal pathogens and maintenance of immune tolerance to dietary antigens, our knowledge of the local adaptations of immunocyte subpopulations remains sparse. In the past few years, the range of monoclonal antibodies to lymphocyte and mononuclear phagocyte (Mph) surface differentiation antigens has greatly increased. Such reagents, often shown capable of distinguishing between functional cell subpopulations, should therefore provide potent tools for the in situ analysis of the gut mucosal immune system.
KeywordsLamina Propria Mononuclear Phagocyte Lymphoid Follicle Mucosal Immune System Lymphoid Aggregate
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