Pleomorphic Adenomas Contain a Keratin-Negative Population of HLA-DR-Positive Dendritic Cells

  • P. S. Thrane
  • L. M. Sollid
  • H. Huitfeldt
  • P. Brandtzaeg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


It is controversial whether myoepithelial cells (MEC) are a major component of pleomorphic adenomas and contribute to their complex histological picture (1–8). MEC, with their stellate appearance and elongated processes have been classified as specialized epithelial cells on the basis of ultra-structural, histochemical and immunohistochemical studies (9). Pleomorphic adenomas have been extensively studied by both ultrastructural (1, 14) and immunohistochemical methods (5,7,8); recent data indicate that the principal tumor cells are modified MEC (8,14).


Dendritic Cell Glial Fibrillary Acidic Protein Myoepithelial Cell Pleomorphic Adenoma Specialized Epithelial Cell 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • P. S. Thrane
    • 1
    • 2
  • L. M. Sollid
    • 1
    • 2
  • H. Huitfeldt
    • 1
    • 2
  • P. Brandtzaeg
    • 1
    • 2
  1. 1.Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Medical FacultyInstitute of PathologyRikshospitaletNorway
  2. 2.Department of Oral Surgery and Oral Medicine, Dental FacultyUniversity of OsloOsloNorway

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