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Molecular Aspects of T Cell Regulation of B Cell Isotype Differentiation

  • M. C. Sneller
  • D. Y. Kunimoto
  • W. Strober
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

One of the questions which has fascinated mucosal immunologists is why the mucosal B cell, i.e., the B cells developing in mucosal lymphoid follicles such as Peyer’s patches, have a greater tendency to become IgA B cells, than B cells in other developmental areas. One theory is based on the supposition that surface IgM-bearing (mIgM-bearing) B cells in the mucosal follicles are more subject to antigen stimulation than cells in other areas and therefore undergo more rounds of cell division. This, in turn, is accompanied by progressive deletion of heavy chain constant region genes and thus the acquisition of IgA because the IgA heavy chain constant region is, at least in the mouse, the ultimate gene in the Ig heavy chain constant region (1,2).

Keywords

Heavy Chain Mucosal Immunity Sezary Syndrome Heavy Chain Constant Region Heavy Chain mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. C. Sneller
    • 1
  • D. Y. Kunimoto
    • 1
  • W. Strober
    • 1
  1. 1.Mucosal Immunity Section, Laboratory of Clinical InvestigationNational Institute of Allergy and Infectious Diseases, NIHBethesdaUSA

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