Molecular Aspects of T Cell Regulation of B Cell Isotype Differentiation

  • M. C. Sneller
  • D. Y. Kunimoto
  • W. Strober
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


One of the questions which has fascinated mucosal immunologists is why the mucosal B cell, i.e., the B cells developing in mucosal lymphoid follicles such as Peyer’s patches, have a greater tendency to become IgA B cells, than B cells in other developmental areas. One theory is based on the supposition that surface IgM-bearing (mIgM-bearing) B cells in the mucosal follicles are more subject to antigen stimulation than cells in other areas and therefore undergo more rounds of cell division. This, in turn, is accompanied by progressive deletion of heavy chain constant region genes and thus the acquisition of IgA because the IgA heavy chain constant region is, at least in the mouse, the ultimate gene in the Ig heavy chain constant region (1,2).


Heavy Chain Mucosal Immunity Sezary Syndrome Heavy Chain Constant Region Heavy Chain mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Cebra, J.J., Fuhrman, J.A., Gearhart, P.J., Horwitz, J.L. and Shahin, R.D., in Recent Advances in Mucosal Immunity, (Edited by Strober, W., Hanson, L.A. and Sell, K.W.), p. 155, Raven Press, New York, 1982.Google Scholar
  2. 2.
    Strober, W. and Jacobs, D., in Advances in Host Defense Mechanisms, Vol. 4, Mucosal Immunity, (Edited by Gallin, J.I. and Fauci, A.S.), p. 1, Raven Press, New York, 1985.Google Scholar
  3. 3.
    Kawanishi, H., Saltzman, L. and Strober, W., J. Exp. Med. 157, 433, 1983.PubMedCrossRefGoogle Scholar
  4. 4.
    Mayer, L., Kwan, S.P., Thompson, C., Ko, H.S., Chiorazzi, N., Waldmann, T.A. and Rosen, R., N. Eng. J. Med. 314, 409, 1986.CrossRefGoogle Scholar
  5. 5.
    Kiyono, H., Mosteller-Barnum, L.M., Pitts, A., Williamson, S., Michalek, S.M. and McGhee, J.R., J. Exp. Med. 161, 731, 1985.PubMedCrossRefGoogle Scholar
  6. 6.
    Yaoita, Y., Kumajar, Y., Okumura, K. and Honjo, T., Nature 297, 697, 1982.PubMedCrossRefGoogle Scholar
  7. 7.
    Stavnezer, J., in Mucosal Immunity and Infections and Mucosal Surfaces, (Edited by Strober, W., Lamm, M., McGhee, J.R. and James, S.P.), Oxford University Press, New York (in press).Google Scholar
  8. 8.
    Noma, Y., Sideras, P., Naito, T., Bergstedt-Lindquist, S., Aguma, C., Severinson, E., Tanabe, T., Kinashi, T., Matsuda, F., Yaoita, Y. and Honjo, T., Nature 314, 640, 1986.CrossRefGoogle Scholar
  9. 9.
    Coffman, R.L., Ohara, J., Bond, M.W., Carty, J., Zlotnick, A. and Paul, W.E., J. Immunol. 136, 4538, 1986.PubMedGoogle Scholar
  10. 10.
    Sen, R. and Baltimore, D., Cell 46, 705, 1986.PubMedCrossRefGoogle Scholar
  11. 11.
    Kawanishi, H., Saltzman, L. and Strober, W., J. Exp. Med. 158, 649, 1983.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. C. Sneller
    • 1
  • D. Y. Kunimoto
    • 1
  • W. Strober
    • 1
  1. 1.Mucosal Immunity Section, Laboratory of Clinical InvestigationNational Institute of Allergy and Infectious Diseases, NIHBethesdaUSA

Personalised recommendations