Molecular Aspects of T Cell Regulation of B Cell Isotype Differentiation
One of the questions which has fascinated mucosal immunologists is why the mucosal B cell, i.e., the B cells developing in mucosal lymphoid follicles such as Peyer’s patches, have a greater tendency to become IgA B cells, than B cells in other developmental areas. One theory is based on the supposition that surface IgM-bearing (mIgM-bearing) B cells in the mucosal follicles are more subject to antigen stimulation than cells in other areas and therefore undergo more rounds of cell division. This, in turn, is accompanied by progressive deletion of heavy chain constant region genes and thus the acquisition of IgA because the IgA heavy chain constant region is, at least in the mouse, the ultimate gene in the Ig heavy chain constant region (1,2).
KeywordsHeavy Chain Mucosal Immunity Sezary Syndrome Heavy Chain Constant Region Heavy Chain mRNA
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