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Antigen-Induced Gastrin Release: An Immunologic Mechanism of Gastric Antral Mucosa

  • H.-J. Krämling
  • G. Enders
  • R. K. Teichmann
  • T. Demmel
  • R. Merkle
  • W. Brendel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

Recent in vivo experiments have shown that the intragastral application of an antigen elicits a hormonal response of gastrin-cells in systemically immunized dogs (1). Further, there was a marked stimulation of antral blood flow and production of mucus. Several factors influence the activity of the stomach in vivo: vagus nerve, gut peptides, acid secretion, and intramural reflexes. An in vitro system (cell-suspension) should eliminate these factors and demonstrate the local mechanisms of antigen specific immunologic reaction of antral mucosa.

Keywords

Vagus Nerve Antral Mucosa Gastrin Release Marked Stimulation Antral Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Teichmann, R.K., Andress, H.J., Gycha, S., Seifert, J., Brendel, W., Gastroenterology 84, 1333, 1983.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • H.-J. Krämling
    • 1
    • 2
  • G. Enders
    • 1
  • R. K. Teichmann
    • 1
    • 2
  • T. Demmel
    • 1
  • R. Merkle
    • 1
  • W. Brendel
    • 1
  1. 1.Department of SurgeryLudwig-Maximilians-UniversityMunichWest Germany
  2. 2.Institute of Surgical Research Klinikum GrosshadernLudwig-Maximilians-UniversityMunichWest Germany

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