Antigen-Induced Gastrin Release: An Immunologic Mechanism of Gastric Antral Mucosa
Recent in vivo experiments have shown that the intragastral application of an antigen elicits a hormonal response of gastrin-cells in systemically immunized dogs (1). Further, there was a marked stimulation of antral blood flow and production of mucus. Several factors influence the activity of the stomach in vivo: vagus nerve, gut peptides, acid secretion, and intramural reflexes. An in vitro system (cell-suspension) should eliminate these factors and demonstrate the local mechanisms of antigen specific immunologic reaction of antral mucosa.
KeywordsVagus Nerve Antral Mucosa Gastrin Release Marked Stimulation Antral Cell
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- 1.Teichmann, R.K., Andress, H.J., Gycha, S., Seifert, J., Brendel, W., Gastroenterology 84, 1333, 1983.Google Scholar