A Model for Paneth Cell Study: Tissue Culture of the Hyperplastic Paneth Cell Population of Rabbit Thiry-Vella Ileal Loops

  • S. E. Kern
  • D. F. Keren
  • T. F. Beals
  • J. Varani
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Paneth cells are characteristically located at the bases of the crypts of Lieberkühn in the small intestine and contain prominent eosinophilic granules. Early studies associated them with a digestive purpose (1,2) and Paneth cells are curiously absent from the mucosa of some carnivores (3). More recent studies have suggested an antibacterial role. The secretory granules of the Paneth cells contain lysozyme (4,5), an enzyme with antibacterial properties (6,7). With ultrastructural studies, Erlandsen identified microorganisms in stages of digestion within phagolysosomes of rat Paneth cells (8,9).


Trypsin Digest Paneth Cell Crypt Depth Ileal Loop Eosinophilic Granule 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • S. E. Kern
    • 1
  • D. F. Keren
    • 1
  • T. F. Beals
    • 1
    • 2
  • J. Varani
    • 1
  1. 1.Department of PathologyThe University of Michigan Medical SchoolUSA
  2. 2.The Veterans Administration Medical CenterAnn ArborUSA

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