Ultrastructural Localization of IgA and IgG in Uterine Epithelial Cells Following Estradiol Administration
The secretory immune system in the reproductive tract of the female mammal is acutely sensitive to stimulation by estradiol (1). Within three hours of each of three daily doses of estradiol to the ovariectomized rat, IgG enters the uterine lumen (2) concomitant with the fluid imbibition phase of estrogen stimulation of the uterus. The levels of IgA in the uterine lumen, on the other hand, do not rise significantly until 32–48 hours of estradiol stimulation (2,3). In order to characterize the morphologic nature of the process of immunoglobulin transport in this polarized epithelial system, we analyzed the distribution patterns of post-embedment immunogold labeling assays of IgA and IgG in uterine epithelial cells at various times of estradiol stimulation.
KeywordsIntermediate Filament Coated Vesicle Uterine Epithelial Cell Uterine Lumen Sodium Metaperiodate
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