Incidence and Distribution of Immunocytes in the Murine Oral Mucosa

  • M. Lacasse
  • A. Collet
  • W. Mourad
  • N. Deslauriers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Specific mucosal defense mechanisms involve the mobilization of the secretory immune system. Even in a healthy individual, secretory immunity is involved in host-bacterial interactions at colonized mucosal surfaces. For example, in the oral cavity of SPF-inbred mice, the colonization and the growth of indigenous bacteria are under the continuous influence of salivary IgA antibodies (1,2). Conversely, it appears that, under normal conditions, the indigenous flora can effectively sensitize the secretory immune system. It is possible that the availability of oral microbial antigens, via retrograde passage through the secretory ducts of minor salivary glands (MSGs) (3), could potentiate IgA antibody production by inducing further proliferation and differentiation of GALT-derived precursor cells (4).


Lamina Propria Paraffin Section Oral Mucosa Soft Palate Minor Salivary Gland 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. Lacasse
    • 1
  • A. Collet
    • 2
  • W. Mourad
    • 1
  • N. Deslauriers
    • 1
  1. 1.Departement de Biochimie and Groupe de Recherche en Ecologie BuccaleUniversité LavalQuébecCanada
  2. 2.Departement d’Anatomie, Faculté de MédecineUniversité LavalQuébecCanada

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