Incidence and Distribution of Immunocytes in the Murine Oral Mucosa
Specific mucosal defense mechanisms involve the mobilization of the secretory immune system. Even in a healthy individual, secretory immunity is involved in host-bacterial interactions at colonized mucosal surfaces. For example, in the oral cavity of SPF-inbred mice, the colonization and the growth of indigenous bacteria are under the continuous influence of salivary IgA antibodies (1,2). Conversely, it appears that, under normal conditions, the indigenous flora can effectively sensitize the secretory immune system. It is possible that the availability of oral microbial antigens, via retrograde passage through the secretory ducts of minor salivary glands (MSGs) (3), could potentiate IgA antibody production by inducing further proliferation and differentiation of GALT-derived precursor cells (4).
KeywordsLamina Propria Paraffin Section Oral Mucosa Soft Palate Minor Salivary Gland
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- 2.Deslauriers, N., Séguin, J. and Trudel, L., Microbiol. Immunol., 1987 (in press).Google Scholar
- 6.Stuart, A.E., Habeshaw, J.A. and Davidson, A.E., II, in Handbook of Experimental Immunology (Edited by Weir, D.M.), p. 31.22, Blackwell Scientific Publications, Oxford, 1978.Google Scholar
- 8.Shelley, W.B. and Juhlin, L., Acta. Dermatovener. (Suppl)79, 7, 1978.Google Scholar
- 12.In Biology of the Laboratory Mouse (Edited by Green, E.L.), p. 251, McGraw-Hill, New York, p. 251, 1966.Google Scholar