Immunohistochemical Analysis of Human Inflammatory Appendix
The digestive mucosal system of laboratory animals has been well studied, particularly in mice and rats where Peyer’s patches are found in clusters clearly visible along the ileum. Most of our knowledge on digestive mucosal immunity has thus been derived from functional immunological studies or from immunohistochemistry in these species (1–3). To apply this information to human physiology is tempting, but remains disputable. Peyer’s patches are macroscopically undetectable in human ileum and this area of the gut can only be obtained post-mortem or during hemicolectomy for a tumor of the right colon, usually in elderly patients (4–6). Although most of its physiological roles remain unknown, the appendix might be an organ useful in assessing the structure and function of the gut-associated lymphoid tissue in young humans. We report here an immunohistological study of the vermiform appendix from 20 patients, obtained at surgery for appendicitis.
KeywordsLamina Propria Vermiform Appendix Interdigitating Cell Dome Area Human Appendix
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