Immunohistochemical Analysis of Human Inflammatory Appendix

  • G. Faure
  • G. Halbgewachs
  • M. C. Bene
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


The digestive mucosal system of laboratory animals has been well studied, particularly in mice and rats where Peyer’s patches are found in clusters clearly visible along the ileum. Most of our knowledge on digestive mucosal immunity has thus been derived from functional immunological studies or from immunohistochemistry in these species (1–3). To apply this information to human physiology is tempting, but remains disputable. Peyer’s patches are macroscopically undetectable in human ileum and this area of the gut can only be obtained post-mortem or during hemicolectomy for a tumor of the right colon, usually in elderly patients (4–6). Although most of its physiological roles remain unknown, the appendix might be an organ useful in assessing the structure and function of the gut-associated lymphoid tissue in young humans. We report here an immunohistological study of the vermiform appendix from 20 patients, obtained at surgery for appendicitis.


Lamina Propria Vermiform Appendix Interdigitating Cell Dome Area Human Appendix 
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  1. 1.
    Faulk, W.P., McCormick, J.N., Goodman, J.R., Yoffey, J.M. and Fudenberg, H.H., Cell. Immunol. 1, 500, 1971.CrossRefGoogle Scholar
  2. 2.
    Sminia, T. and Plesch, B.E.C., Virchows Arch. (Cell. Pathol.) 40, 181, 1982.CrossRefGoogle Scholar
  3. 3.
    Bookman, D.E., Arch. Histol. Jap. 46, 271, 1983.CrossRefGoogle Scholar
  4. 4.
    Spencer, J., Finn, T. and Isaacson, P.G., Gut 26, 672, 1985.PubMedCrossRefGoogle Scholar
  5. 5.
    Spencer, J., Finn, T. and Isaacson, P.G., Gut 27, 405, 1986.PubMedCrossRefGoogle Scholar
  6. 6.
    Bjerke, K., Brandtzaeg, P. and Rognum, T.O., Gut 27, 667, 1986.PubMedCrossRefGoogle Scholar
  7. 7.
    Anderson, K.C., Bates, M.P., Slaughenhoupt, B.L., Pinkus, G.L., Schlossman, S.F. and Nadler, L.M., Blood 63, 1424, 1984.PubMedGoogle Scholar
  8. 8.
    Selby, W.S., Janossy, G. and Jewell, D.P., Gut 22, 169, 1981.PubMedCrossRefGoogle Scholar
  9. 9.
    Scott, H., Solheim, B.G., Brandtzaeg, P. and Thorsby, E., Scand. J. Immunol. 12, 77, 1980.PubMedCrossRefGoogle Scholar
  10. 10.
    Bjerke, K. and Brandtzaeg, P., Scand. J. Immunol. 18, 71, 1983.Google Scholar
  11. 11.
    Sminia, T., Hendriks, H.R., Janse, M. and Van De Ende, M., Virchows Arch. (Cell. Pathol.) 47, 123, 1984.CrossRefGoogle Scholar
  12. 12.
    Van der Jeijden, D., Nieweg, O., Rijkmans, B., Stikker, R., Opstelten, D. and Nieuwenhuis, P., Virchows Arch. (Cell. Pathol.) 34, 43, 1980.CrossRefGoogle Scholar
  13. 13.
    Toma, V.A. and Retief, R.P., J. Immunol. Methods 20, 333, 1978.PubMedCrossRefGoogle Scholar
  14. 14.
    Butcher, E.C., Rouse, R.V., Coffman, R.L., Nottenburg, C.N., Hardy, R.R. and Weissman, I.L., J. Immunol. 129, 2698, 1982.PubMedGoogle Scholar
  15. 15.
    Phillips-Quagliata, J.M., Roux, M.E., Amy, M., Kelly-Hatfield, P., McWilliams, M. and Lamm, M.E., Ann. N.Y. Acad. Sci. 409, 194, 1983.PubMedCrossRefGoogle Scholar
  16. 16.
    Selby, W.S., Poulter, L.W., Hobbs, S., Jewell, D.P. and Janossy, G., J. Clin. Pathol. 36 379, 1983.PubMedCrossRefGoogle Scholar
  17. 17.
    Spencer, J., Finn, T. and Isaacson, P.G., Gut 27, 153, 1986.PubMedCrossRefGoogle Scholar
  18. 18.
    Bene, M.C., Moneret-Vautrin, D.A. and Faure, G.C., 6th Int. Congress of Immunology, Toronto, 1.41.33 1986.Google Scholar
  19. 19.
    Cerf-Bensussan, N., Schneeberger, E.E. and Bhan, A.K., J. Immunol. 130, 2615, 1983.PubMedGoogle Scholar
  20. 20.
    Stein, H., Bonk, A., Tolksdorf, G., Lennert, K., Rodt, H. and Gerdes, J., J. Histochem. Cytochem. 28, 746, 1980.PubMedCrossRefGoogle Scholar
  21. 21.
    Berry, J.A. and Lack, L.A.H., J. Anat. Physiol. 40. 247, 1905.Google Scholar
  22. 22.
    Butler, C., Human Pathol. 12, 870, 1981.CrossRefGoogle Scholar
  23. 23.
    O’Brien, A. and O’Briain, D.S., Arch. Pathol. Lab. Med. 109, 680, 1985.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • G. Faure
    • 1
  • G. Halbgewachs
    • 1
  • M. C. Bene
    • 1
  1. 1.Laboratoire d’Immunologie UFR Sciences MedicalesUniversite de Nancy IVandoeuvre les NancyFrance

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