Altered Patterns of Secretion of IgA and IgG Subclasses by Ulcerative Colitis and Crohn’s Disease Intestinal Mononuclear Cells

  • R. P. MacDermott
  • G. S. Nash
  • M. G. Scott
  • M. H. Nahm
  • M. J. Bertovich
  • I. J. Kodner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Ulcerative colitis (UC) and Crohn’s disease (CD) are inflammatory bowel diseases (IBD) due to unknown etiologic and potentiating factors resulting in immune responses of a chronic inflammatory nature (1). There is an increase in cytoplasmic, surface, and secreted antibodies from IBD intestinal lymphocytes, due mainly to enhanced expression and production of IgG (2–4). In previous studies (5,6) we have found that immunoglobulin secretion patterns by peripheral blood and intestinal mononuclear cells (MNC) from inflammatory bowel disease patients is altered. IBD peripheral blood MNC reveal a markedly increased spontaneous secretion of IgA which is partially suppressed by PWM (5,6). Intestinal MNC from control specimens also spontaneously secrete large amounts of IgA, which is suppressed by PWM (5,6). In IBD patients, intestinal MNC exhibit decreased spontaneous IgA secretion, but have increased IgG secretion compared with control intestinal MNC (5–7). The changes in antibody secretion observed in IBD could be due to: (a) preferential proliferation of subpopulations of cells due to immunoregulatory alteration; (b) switching of the isotype and/or subclass of antibody secreted by the lymphocytes themselves; or (c) changes in the homing and trafficking patterns of the lymphocytes due to the inflammatory process.


Inflammatory Bowel Disease Ulcerative Colitis Spontaneous Secretion Intestinal Lymphocyte Preferential Proliferation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Kirsner, J.B. and Shorter, R.G., N. Engl. J. Med. 306, 775, 1982.PubMedCrossRefGoogle Scholar
  2. 2.
    Brandtzaeg, P., Baklien, K., Fausa, O. and Hoel, P.S., Gastroenterology 66, 1123, 1974.PubMedGoogle Scholar
  3. 3.
    Baklien, K. and Brandtzaeg, P., Clin. Exp. Immunol. 22, 197, 1975.PubMedGoogle Scholar
  4. 4.
    Baklien, K. and Brandtzaeg, P., Scand. J. Gastroent. 11, 447, 1976.PubMedGoogle Scholar
  5. 5.
    MacDermott, R.P., Nash, G.S., Bertovich, M.J., Seiden, M.V., Bragdon, M.J. and Beale, M.G., Gastroenterology 81, 844, 1981.PubMedGoogle Scholar
  6. 6.
    MacDermott, R.P., Beale, M.G., Alley, C.D., Nash, G.S., Bertovich, M.J. and Bragdon, M.J., Ann. N.Y. Acad. Sci. 409, 498, 1983.PubMedCrossRefGoogle Scholar
  7. 7.
    Bookman, M.A. and Bull, D.M., Gastroenterology 77, 503, 1979.PubMedGoogle Scholar
  8. 8.
    Bull, D.M. and Bookman, M.A., J. Clin. Invest. 59, 966, 1977.PubMedCrossRefGoogle Scholar
  9. 9.
    MacDermott, R.P., Nash, G.S., Bertovich, M.J., Mohrman, R.F., Kidner, I.J., Delacroix, D.L. and Vaerman, J.-P., Gastroenterology 91, 379, 1986.PubMedGoogle Scholar
  10. 10.
    Scott, M.G., Nahm, M.H., Macke, K., Nash, G.S., Bertovich, M.J. and MacDermott, R.P., Clin. Exp. Immunol. 66, 209, 1986.PubMedGoogle Scholar
  11. 11.
    Alley, C.D. and MacDermott, R.P., Blood 55, 669, 1980.PubMedGoogle Scholar
  12. 12.
    Alley, C.D., Nash, G.S. and MacDermott, R.P., J. Immunol. 128, 2804, 1982.Google Scholar
  13. 13.
    Nash, G.S., Seiden, M.V., Beale, M.G. and MacDermott, R.P., J. Immunol. Meth. 49, 261, 1982.CrossRefGoogle Scholar
  14. 14.
    Beale, M.G., Nash, G.S., Bertovich, M.J. and MacDermott, R.P., J. Immunol. 128, 486, 1982.PubMedGoogle Scholar
  15. 15.
    Delacroix, D.L., Elkon, K.B., Geubel, A.P., Hodgson, H.F., Dive, C. and Vaerman, J.-P., J. Clin. Invest. 71, 358, 1983.PubMedCrossRefGoogle Scholar
  16. 16.
    Scott, M.G. and Nahm, M.H., J. Immunol. 133, 2454, 1984.PubMedGoogle Scholar
  17. 17.
    MacDermott, R.P., in Recent Advances in Crohn’s Disease, (Edited by Pena, A.S., Weterman, I.T., Booth, C.C. and Strober, W.), p. 439, Martinus Nijhoff Publishers, The Hague, 1981.CrossRefGoogle Scholar
  18. 18.
    Kutteh, W.H., Prince, S.J. and Mestecky, J., J. Immunol. 128, 990, 1982.PubMedGoogle Scholar
  19. 19.
    Kutteh, W.H., Koopman, W.J., Conley, M.E., Egan, M.L. and Mestecky, J., J. Exp. Med. 152, 1424, 1980.PubMedCrossRefGoogle Scholar
  20. 20.
    Delacroix, D.L., Dive, C., Rambaud, J.C. and Vaerman, J.-P., Immunology 47, 383, 1982.PubMedGoogle Scholar
  21. 21.
    Danis, V.A., Harries, A.D., and Heatley, R.V., Clin. Exp. Immunol. 56, 159, 1984.PubMedGoogle Scholar
  22. 22.
    Oxelius, V.A., Laurell, A.B., Lindquist, B., Goleblowaska, H., Axelsson, U., Bjorkander, J. and Hanson, L.Å., N. Engl. J. Med. 304, 1476, 1981.PubMedCrossRefGoogle Scholar
  23. 23.
    Oxelius, V.A., Am. J. Med. 76, 7, 1984.PubMedCrossRefGoogle Scholar
  24. 24.
    Waldmann, T.A., Broder, S., Goldman, C.K., Frost, K., Korsmeyer, S.J. and Medici, M.A., J. Clin. Invest. 71, 282, 1983.PubMedCrossRefGoogle Scholar
  25. 25.
    Yount, W.J., N. Engl. J. Med. 306, 541, 1982.PubMedCrossRefGoogle Scholar
  26. 26.
    Shakib, F. and Stanworth, D.R., La Ricerca Clin. Lab. 10, 561, 1980.CrossRefGoogle Scholar
  27. 27.
    Slack, J., Der-Balian, G.P., Nahm, M.H. and Davie, J.M., J. Exp. Med. 151, 853, 1980.PubMedCrossRefGoogle Scholar
  28. 28.
    Yount, W.J., Dorner, M.M., Kunkel, H.G. and Kabat, E.A., J. Exp. Med. 127, 633, 1968.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • R. P. MacDermott
    • 1
  • G. S. Nash
    • 1
  • M. G. Scott
    • 1
  • M. H. Nahm
    • 1
  • M. J. Bertovich
    • 1
  • I. J. Kodner
    • 1
  1. 1.Divisions of Gastroenterology and Laboratory Medicine Departments of Medicine, Pathology and Surgery, Barnes and Jewish HospitalsWashington University Medical CenterSt. LouisUSA

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