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Subclass Distribution of IgG- and IgA-Producing Cells in Secretory Tissues and Alterations Related to Gut Diseases

  • P. Brandtzaeg
  • K. Kett
  • T. O. Rognum
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

Both serum IgA and secretory IgA (sIgA) consist of two subclasses, IgAl and IgA2, which differ in primary structure, carbohydrate composition, and antigenic properties (1). While IgAl predominates (about 90%) in normal serum, exocrine secretions have been reported to contain a relatively large proportion (30–50%) of IgA2 (2,3). It is not known how IgA subclass production is regulated; apparently contradictory information about the influence of antigenic stimuli has been published (4–7).

Keywords

Ulcerative Colitis Food Allergy Nasal Mucosa Coeliac Disease Lacrimal Gland 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • P. Brandtzaeg
    • 1
  • K. Kett
    • 1
  • T. O. Rognum
    • 1
  1. 1.Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, and Institute of Forensic MedicineThe National HospitalOslo 1Norway

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