Subclass Distribution of IgG- and IgA-Producing Cells in Secretory Tissues and Alterations Related to Gut Diseases

  • P. Brandtzaeg
  • K. Kett
  • T. O. Rognum
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Both serum IgA and secretory IgA (sIgA) consist of two subclasses, IgAl and IgA2, which differ in primary structure, carbohydrate composition, and antigenic properties (1). While IgAl predominates (about 90%) in normal serum, exocrine secretions have been reported to contain a relatively large proportion (30–50%) of IgA2 (2,3). It is not known how IgA subclass production is regulated; apparently contradictory information about the influence of antigenic stimuli has been published (4–7).


Ulcerative Colitis Food Allergy Nasal Mucosa Coeliac Disease Lacrimal Gland 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Mestecky, J. and Russell, M.W., Monogr. Allergy 19, 277, 1986.PubMedGoogle Scholar
  2. 2.
    Grey, H.M., Abel, C.A., Yount, W.J. and Kunkel, H.G., J. Exp. Med. 128, 1223, 1968.PubMedCrossRefGoogle Scholar
  3. 3.
    Delacroix, D.L., Dive, C., Rambaud, J.C. and Vaerman, J.-P., Immunology 47, 383, 1982.PubMedGoogle Scholar
  4. 4.
    Brown, T.A. and Mestecky, J., Infect. Immun. 49, 459, 1985.PubMedGoogle Scholar
  5. 5.
    Brown, T.A., Murphy, B.R., Radl, J., Haaijman, J.J. and Mestecky, J., J. Clin. Microbiol. 22, 259, 1985.PubMedGoogle Scholar
  6. 6.
    Conley, M.E. and Briles, D.E., Immunology 53, 419, 1984.PubMedGoogle Scholar
  7. 7.
    Hammarstrom, L., Persson, M.A.A. and Smith, C.I.E., Immunology 54, 821, 1985.PubMedGoogle Scholar
  8. 8.
    Conley, M.E., Kearney, J.F., Lawton, A.R. and Cooper, M.D., J. Immunol. 125, 2311, 1980.PubMedGoogle Scholar
  9. 9.
    Conley, M.E. and Bartelt, M.S., J. Immunol. 133, 2312, 1984.PubMedGoogle Scholar
  10. 10.
    Brandtzaeg, P., Prot. Biol. Fluids 12, 363, 1985.Google Scholar
  11. 11.
    Brandzaeg, P., Gjeruldsen, S.T., Korsrud, F., Baklien, K., Berdal, P. and Ek, J., J. Immunol. 122, 503, 1979.Google Scholar
  12. 12.
    Brandtzaeg, P., Vaines, K., Scott, H., Rognum, T.O., Bjerke, K. and Baklien, K., Scand. J. Gastroent. 20 (Suppl. 114), 17, 1985.CrossRefGoogle Scholar
  13. 13.
    Shakib, F. and Stanworth, D.R., Ricerca Clin. Lab. 10, 561, 1980.Google Scholar
  14. 14.
    Maymui, M., Kuritani, T., Kubagawa, H. and Cooper, M.D., J. Immunol. 130, 671, 1983.Google Scholar
  15. 15.
    Brandtzaeg, P., Kett, K., Rognum, T.O., Söderstrom, R., Bjorkander, J., Söderstrom, T., Petruson, B. and Hanson, L.Â., Monogr. Allergy 20, 179, 1986.PubMedGoogle Scholar
  16. 16.
    Brandtzaeg, P., Karlsson, G., Hansson, G., Petruson, B., Bjorkander, J. and Hanson, L.Å., Clin. Exp. Immunol., 1987 (in press).Google Scholar
  17. 17.
    Kett, K., Brandtzaeg, P., Radl, J. and Haaijdman, J.J., J. Immunol. 136, 3631, 1986.PubMedGoogle Scholar
  18. 18.
    Kett, K., Rognum, T.O. and Brandtzaeg, P., Gastroenterology, 1987 (in press).Google Scholar
  19. 19.
    Kett, K. and Brandtzaeg, P., Gut, 1987 (in press).Google Scholar
  20. 20.
    Rognum, T.O., Kett, K., Bengtsson, U., Scott, H. and Brandtzaeg, P., Gut, 1987 (in press).Google Scholar
  21. 21.
    Brandtzaeg, P., Immunology 26, 1101, 1974.PubMedGoogle Scholar
  22. 22.
    Jefferis, R., Reimer, C.B., Skvaril, F., de Lange, G., Ling, N.R., Lowe, J., Walker, M.R., Phillips, D.J., Aloisio, C.H., Wells, T.W., Vaerman, J.-P., Magnusson, C.G., Kubagawa, H., Cooper, M., Vartdal, F., Vandvik, B., Haaijman, J.J., Makela, O., Sarnesto, A., Lando, Z., Gergely, J., Rajnavolgyi, E., Laszlo, G., Radl, J. and Molinaro, G.A., Immun. Letters 10, 223, 1985.CrossRefGoogle Scholar
  23. 23.
    Valentijn, R.M., Radl, J., Haaijman, J.J., Vermeer, B.J., Weening, J.J., Kauffman, R.H., Daha, M.R. and van Es, L.A., Kidney Internat. 26, 760, 1984.CrossRefGoogle Scholar
  24. 24.
    Scott, M.G., Macke, K., Nash, G., McDermott, R. and Nahm, M., Fed. Proc. 44, Abstr. No. 7631, 1985.Google Scholar
  25. 25.
    Freijd, A., Hammarstrom, L., Persson, M.A.A. and Smith, C.I.E., Clin. Exp. Immunol. 56, 233, 1984.PubMedGoogle Scholar
  26. 26.
    Linde, G.A., Hammarstrom, L., Persson, M.A.A., Smith, C.I.E., Sundqvist, V.A. and Wahren, B., Infect. Immun. 42, 237, 1983.PubMedGoogle Scholar
  27. 27.
    Skvaril, F. and Schilt, U., Clin. Exp. Immunol. 55, 671, 1984.PubMedGoogle Scholar
  28. 28.
    Hornsleth, A., Bech-Thomsen, N. and Friis, B., J. Med. Virol. 16, 321, 1985.PubMedCrossRefGoogle Scholar
  29. 29.
    Siber, G.R., Schur, P.H., Aisenberg, A.C., Weitzman, S.A. and Schiffman, G., N. Engl. J. Med. 303, 178, 1980.PubMedCrossRefGoogle Scholar
  30. 30.
    Scott, M.G. and Nahm, M.H., J. Immunol. 135, 2454, 1984.Google Scholar
  31. 31.
    Kagnoff, M.F., Brown, R.J. and Schanfield, M.S., Gastroenterology 85, 1044, 1983.PubMedGoogle Scholar
  32. 32.
    Kagnoff, M.F., Weiss, J.B., Brown, R.J., Lee, T. and Schanfield, M.S., Lancet 1, 952, 1983.PubMedCrossRefGoogle Scholar
  33. 33.
    Weiss, J.B., Austin, R.K., Schanfield, M.S. and Kagnoff, M.F., J. Clin. Invest. 72, 96, 1983.PubMedCrossRefGoogle Scholar
  34. 34.
    Crago, S.D., Kutteh, W.H., Moro, I., Allansmith, M.R., Radl, J., Haaijman, J.J. and Mestecky, J., J. Immunol. 132, 16, 1984.PubMedGoogle Scholar
  35. 35.
    Andre, C., Andre, F. and Fargier, M.C., Clin. Exp. Immunol. 33, 327, 1978.PubMedGoogle Scholar
  36. 36.
    Allansmith, M.R., Radl, J., Haaijman, J.J. and Mestecky, J., J. Allergy Clin. Immun. 76, 569, 1986.CrossRefGoogle Scholar
  37. 37.
    Brandtzaeg, P., Scand. J. Gastroent. 20 (Suppl. 114), 137, 1985.CrossRefGoogle Scholar
  38. 38.
    Cebra, J.J., Fuhrman, J.A., Horsfall, D.J. and Shahin, R.D., Seminars in Infectious Disease, (Edited by Weinstein, L. and Fields, B.), Bacterial Vaccines, Vol. 4, (Edited by Robbins, J.B., Hill, J.C. and Sadoff, J.C), p. 6, Thieme-Stratton, New York, 1982.Google Scholar
  39. 39.
    Flanagan, J.G. and Rabbits, T.H., Nature 300, 709, 1982.PubMedCrossRefGoogle Scholar
  40. 40.
    Hammarstrom, L., Mellstedt, H., Persson, M.A.A., Smith, C.I.E. and Ahre, A., Acta. Path. Microbiol. Immunol. Scand. Sect. C 92, 207, 1984.Google Scholar
  41. 41.
    Mayer, L., Posnett, D.N. and Kunkel, H.G., J. Exp. Med. 161, 134, 1985.PubMedCrossRefGoogle Scholar
  42. 42.
    Brandtzaeg, P., Ann. N.Y. Acad. Sci. 409, 353, 1983.PubMedCrossRefGoogle Scholar
  43. 43.
    Brandtzaeg, P. and Korsrud, F.R., Clin. Exp. Immunol. 58, 709, 1984.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • P. Brandtzaeg
    • 1
  • K. Kett
    • 1
  • T. O. Rognum
    • 1
  1. 1.Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, and Institute of Forensic MedicineThe National HospitalOslo 1Norway

Personalised recommendations