Properties of Human B Cells Terminating in Normal Gut-Associated Lymphoid Tissue, Including Peyer’s Patches
The intestinal secretory IgA system is quantitatively the most important humoral immune system of the body — about 1010 Ig-producing cells being present per metre of gut (1). The precursors of these immunocytes are apparently generated largely in the Peyer’s patches owing to specialized mechanisms of antigen uptake and immune regulation (2,3). Lymphoid follicles of the appendix and solitary follicles scattered throughout the small and large bowel mucosa, show comparable features and may function as a part of the gut-associated lymphoid tissue (GALT). A comparative study of the immunoglobulin (Ig) isotype expression of B cells associated with lymphoid follicles of the appendix, colon and ileum mucosa and in Peyer’s patches was therefore carried out. Cytoplasmic J chain was included as a marker of clonal immaturity (4) to study the extent of terminal B cell maturation in situ.
KeywordsLamina Propria Germinal Centre Tissue Compartment Lymphoid Follicle Clonal Immaturity
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